distemper

to trouble the mind of; to make uneasy despite his career success, he has been distempered by nagging feelings of inadequacy his whole life Synonyms agitate, ail, alarm (also alarum), bother, concern, derail, discomfort, discompose, dismay, disquiet, disturb, distract, distress, exercise, flurry, frazzle, freak (out), fuss, hagride, perturb, undo, unhinge, unsettle, upset, weird out, worryRelated Words aggravate, anger, annoy, bug, chafe, chivy (or chivvy), exasperate, fret, gall, get, grate, harass, harry, irk, irritate, nettle, peeve, pester, pique, put off, put out, rile, vex; bedevil, haunt, plague; abash, confound, confuse, discomfit, disconcert, discountenance, embarrass, faze, fluster, jar, mortify, nonplus, rattle, shake up; daunt, demoralize, discourage, dishearten, dispirit, unnerveNear Antonyms allay, alleviate, assuage; appease, conciliate, mollify, pacify, placate, propitiateAntonyms calm, compose, quiet, settle, soothe, tranquilize (also tranquillize)