disease

noun

dis·​ease di-ˈzēz How to pronounce disease (audio)
Synonyms of diseasenext
1
: a condition of the living animal or plant body or of one of its parts that impairs normal functioning and is typically manifested by distinguishing signs and symptoms : sickness, malady
infectious diseases
a rare genetic disease
heart disease
2
: a harmful development (as in a social institution)
sees the city's crime as a disease
3
obsolete : trouble

Examples of disease in a Sentence

He suffers from a rare genetic disease. a disease of the mind Thousands die of heart disease each year. They are working to stop the spread of disease in rural areas. The article cites intolerance as one of the most dangerous of society's diseases. He sees crime as a disease that too often plagues the poor and disadvantaged.
Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
The finding has the potential to provide a longer runway to make the lifestyle changes that can help reduce risk, and could be used to better identify subjects who could benefit from participating in clinical trials seeking to prevent or treat neurodegenerative disease. Paul Sisson, San Diego Union-Tribune, 12 Mar. 2026 Hall of Fame high school football coach Bob Johnson, who built powerhouse programs at El Toro and Mission Viejo and became known for mentoring for his sons and other top quarterbacks, died Wednesday after a long fight with Alzheimer’s disease, his son Bret confirmed. Dan Albano, Oc Register, 12 Mar. 2026 Key Takeaways The symptoms of transthyretin amyloid cardiomyopathy (ATTR-CM)—a disease of the heart muscle—are often subtle and can mimic those of other heart conditions, especially in the early stages. Colleen Doherty, Verywell Health, 11 Mar. 2026 Other signs discussed non-native plant species and the negative effects of feral horses, information about disease, enslavement, war, and colonization, and how government regulations protect delicate ecosystems. Madison Dapcevich, Outside, 11 Mar. 2026 See All Example Sentences for disease

Word History

Etymology

Middle English disese, from Anglo-French desease, desaise, from des- dis- + eise ease

First Known Use

14th century, in the meaning defined at sense 3

Time Traveler
The first known use of disease was in the 14th century

Browse Nearby Words

Cite this Entry

“Disease.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/disease. Accessed 17 Mar. 2026.

Kids Definition

disease

noun
dis·​ease diz-ˈēz How to pronounce disease (audio)
: an abnormal bodily condition of a living plant or animal that interferes with functioning and can usually be recognized by signs and symptoms : illness
diseased adjective

Medical Definition

disease

noun
dis·​ease diz-ˈēz How to pronounce disease (audio)
: an impairment of the normal state of the living animal or plant body or one of its parts that interrupts or modifies the performance of the vital functions, is typically manifested by distinguishing signs and symptoms, and is a response to environmental factors (as malnutrition, industrial hazards, or climate), to specific infective agents (as worms, bacteria, or viruses), to inherent defects of the organism (as genetic anomalies), or to combinations of these factors : sickness, illness

called also morbus

compare health sense 1
diseased adjective

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