Castleman disease

noun
Cas·​tle·​man disease | \ ˈka-səl-mən- How to pronounce Castleman disease (audio) \
variants: or Castleman's disease \ ˈka-​səl-​mənz-​ How to pronounce Castleman disease (audio) \

Definition of Castleman disease

: a rare disease of the lymphatic system that is marked by nonmalignant overgrowth of lymphoid tissue and lymph node enlargement and that occurs either in a localized or a systemic form

Note: The localized form of Castleman disease affects a single lymph node or single group of lymph nodes (as in the chest or abdomen) and is often asymptomatic. The systemic form affects multiple groups of lymph nodes and causes flulike symptoms (such as fatigue, fever, and weight loss), edema, neuropathy, life-threatening infection, enlargement of the liver or spleen, or kidney dysfunction.

called also angiofollicular lymph node hyperplasia, giant lymph node hyperplasia

First Known Use of Castleman disease

1978, in the meaning defined above

History and Etymology for Castleman disease

after Benjamin Castleman †1982 U.S. pathologist, principal author of a description of the disease

Note: The disease was described by Benjamin Castleman, Lalla Iverson, and V. Pardo Menendez in "Localized mediastinal lymph-node hyperplasia resembling thymoma," Cancer, vol. 9, issue 4 (July-August, 1956), pp. 822-30.

Learn More About Castleman disease

Time Traveler for Castleman disease

Time Traveler

The first known use of Castleman disease was in 1978

See more words from the same year

Dictionary Entries Near Castleman disease

castle in the air

Castleman disease

castle nut

See More Nearby Entries 

Statistics for Castleman disease

Cite this Entry

“Castleman disease.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/Castleman%20disease. Accessed 2 Dec. 2021.

Style: MLA
MLACheck Mark Icon ChicagoCheck Mark Icon APACheck Mark Icon Merriam-WebsterCheck Mark Icon

WORD OF THE DAY

Test Your Vocabulary

Farm Idioms Quiz

  • cow coming home
  • What does 'poke' refer to in the expression 'pig in a poke'?
Spell It

Can you spell these 10 commonly misspelled words?

TAKE THE QUIZ
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!