Paget's disease

noun

Pag·​et's disease ˈpa-jəts- How to pronounce Paget's disease (audio)
1
: a rare form of breast cancer initially manifested as a scaly red rash on the nipple and areola
2
or Paget's disease of bone : a chronic disease that is characterized by one or more enlarged, weak bones (such as of the pelvis, spine, or skull) and may be marked by bone pain but is often asymptomatic

Note: Paget's disease is caused by a high level of bone resorption by osteoclasts followed by rapid formation of structurally unsound bone by osteoblasts. Symptoms include bowing of the long bones, deformation of the skull and pelvis, and abnormal fractures occurring in weakened bone.

Examples of Paget's disease in a Sentence

Recent Examples on the Web Most people with Paget's disease also develop cancerous tumors in their breast tissue. Melissa Matthews, Men's Health, 31 May 2023 There was no evidence found for conditions hypothesized by some experts such as otosclerosis or Paget's disease, Begg said. Fox News, 25 Mar. 2023

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'Paget's disease.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

Etymology

Sir James Paget †1899 English surgeon

First Known Use

1880, in the meaning defined at sense 1

Time Traveler
The first known use of Paget's disease was in 1880

Dictionary Entries Near Paget's disease

Cite this Entry

“Paget's disease.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/Paget%27s%20disease. Accessed 22 Feb. 2024.

Medical Definition

Paget's disease

noun
Pag·​et's disease ˌpaj-əts- How to pronounce Paget's disease (audio)
1
: a rare form of breast cancer initially manifested as a scaly red rash on the nipple and areola
2
or Paget's disease of bone : a chronic disease that is characterized by one or more enlarged, weak bones (such as of the pelvis, spine, or skull) and may be marked by bone pain but is often asymptomatic

Note: Paget's disease is caused by a high level of bone resorption by osteoclasts followed by rapid formation of structurally unsound bone by osteoblasts. Bowing of the long bones, deformation of the flat bones, and abnormal fractures occur in the weakened bone.

called also osteitis deformans, osteodystrophia deformans

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