Paget's disease

noun
Pag·​et's disease | \ ˈpa-jəts- How to pronounce Paget's disease (audio) \

Definition of Paget's disease

1 : a rare form of breast cancer initially manifested as a scaly red rash on the nipple and areola
2 or Paget's disease of bone : a chronic disease that is characterized by one or more enlarged, weak bones (such as of the pelvis, spine, or skull) and may be marked by bone pain but is often asymptomatic

Note: Paget's disease is caused by a high level of bone resorption by osteoclasts followed by rapid formation of structurally unsound bone by osteoblasts. Symptoms include bowing of the long bones, deformation of the skull and pelvis, and abnormal fractures occurring in weakened bone.

First Known Use of Paget's disease

1880, in the meaning defined at sense 1

History and Etymology for Paget's disease

Sir James Paget †1899 English surgeon

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The first known use of Paget's disease was in 1880

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Cite this Entry

“Paget's disease.” The Merriam-Webster.com Dictionary, Merriam-Webster Inc., https://www.merriam-webster.com/dictionary/Paget%27s%20disease. Accessed 22 November 2019.

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More Definitions for Paget's disease

Paget's disease

noun
Pag·​et's disease | \ ˌpaj-əts- How to pronounce Paget's disease (audio) \

Medical Definition of Paget's disease

1 : a rare form of breast cancer initially manifested as a scaly red rash on the nipple and areola
2 or Paget's disease of bone : a chronic disease that is characterized by one or more enlarged, weak bones (such as of the pelvis, spine, or skull) and may be marked by bone pain but is often asymptomatic

Note: Paget's disease is caused by a high level of bone resorption by osteoclasts followed by rapid formation of structurally unsound bone by osteoblasts. Bowing of the long bones, deformation of the flat bones, and abnormal fractures occur in the weakened bone.

called also osteitis deformans, osteodystrophia deformans

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