osteoclast

noun

os·​te·​o·​clast ˈä-stē-ə-ˌklast How to pronounce osteoclast (audio)
: any of the large multinucleate cells closely associated with areas of bone resorption
osteoclastic adjective

Examples of osteoclast in a Sentence

Recent Examples on the Web Having narrowed down the likely culprit, the researchers sought to target and remove the senescent osteoclasts. William A. Haseltine, Forbes, 11 Dec. 2023 But in certain situations, the osteoclasts ended up misbehaving, leading to excessive pore formation in the endplates of the spine. William A. Haseltine, Forbes, 11 Dec. 2023 Meanwhile, in the marrow cavity, osteoclasts are eroding the bone that was deposited early in life, and other cells are making secondary bone tissue along the perimeter of the cavity or invading the cortex (outer layer) of the remaining bone to remodel it. Kevin Padian, Scientific American, 1 May 2014 Cells called osteoclasts hollow out the center of a long bone, such as the femur (thigh) or tibia (shin), by breaking down existing bone and allowing its nutrients to be recycled. Kevin Padian, Scientific American, 1 May 2014 Resorption is the breakdown of old bones by osteoclasts, a type of bone cell. Susan Scutti, CNN, 8 May 2017 The first, osteoclasts, break down bone tissue as part of the process of repairing and maintaining any damage. Danny Lewis, Smithsonian, 16 Jan. 2017 See More

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'osteoclast.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

Etymology

International Scientific Vocabulary oste- + Greek klastos broken — more at clast

First Known Use

1872, in the meaning defined above

Time Traveler
The first known use of osteoclast was in 1872

Dictionary Entries Near osteoclast

Cite this Entry

“Osteoclast.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/osteoclast. Accessed 2 Mar. 2024.

Medical Definition

osteoclast

noun
os·​teo·​clast ˈäs-tē-ə-ˌklast How to pronounce osteoclast (audio)
1
: any of the large multinucleate cells closely associated with areas of bone resorption (as in a fracture that is healing) compare chondroclast
2
: an instrument for performing osteoclasis
osteoclastic adjective

More from Merriam-Webster on osteoclast

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