Huntington's disease

noun

Hun·​ting·​ton's disease ˈhən-tiŋ-tənz- How to pronounce Huntington's disease (audio)
variants or less commonly Huntington disease or Huntington's chorea or Huntington's
: a hereditary brain disorder that is a progressive, neurodegenerative condition marked especially by impairments in thinking and reasoning, disturbances of emotion and behavior, and the involuntary spasmodic movements of chorea and that is associated with the loss or atrophy of nerve cells in the basal ganglia especially of the caudate nucleus and putamen

Note: Huntington's disease is inherited as an autosomal dominant trait requiring only one parent to pass on a copy of the defective gene on a chromosome other than a sex chromosome. While it may have an onset at any age, people most often become symptomatic between 30 to 50 years of age. The most common symptoms of Huntington's disease include depression, irritability, mood swings, deficits in memory and concentration, dementia, difficulty in swallowing, jerky movements, and loss of coordination.

Word History

Etymology

George Huntington †1916 American physician

First Known Use

1887, in the meaning defined above

Time Traveler
The first known use of Huntington's disease was in 1887

Dictionary Entries Near Huntington's disease

Cite this Entry

“Huntington's disease.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/Huntington%27s%20disease. Accessed 4 Feb. 2023.

Kids Definition

Huntington's disease

noun
Hun·​ting·​ton's disease ˈhənt-iŋ-tənz- How to pronounce Huntington's disease (audio)
: an inherited nervous disorder that develops in adult life and leads to severely reduced mental functioning

Medical Definition

Huntington's disease

noun
Hun·​ting·​ton's disease ˌhənt-iŋ-tənz- How to pronounce Huntington's disease (audio)
variants also Huntington disease or Huntington's chorea or Huntington's
: a hereditary brain disorder that is a progressive, neurodegenerative condition marked especially by impairments in thinking and reasoning, disturbances of emotion and behavior, and the involuntary spasmodic movements of chorea and is associated with the loss or atrophy of nerve cells in the basal ganglia especially of the caudate nucleus and putamen

Note: Huntington's disease is inherited as an autosomal dominant trait requiring only one parent to pass on a copy of the defective gene on a chromosome other than a sex chromosome. While it may have an onset at any age, people most often become symptomatic between 30 to 50 years of age. The most common symptoms of Huntington's disease include depression, irritability, mood swings, deficits in memory and concentration, dementia, difficulty in swallowing, jerky movements, and loss of coordination.

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