Definition of prion disease
: any of a group of spongiform encephalopathies that are caused by prions and that include bovine spongiform encephalopathy, Creutzfeldt-Jakob disease, kuru, scrapie, and variant Creutzfeldt-Jakob disease
— called also transmissible spongiform encephalopathy
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Merriam-Webster unabridged
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Time Traveler for prion disease
The first known use of prion disease was in 1986
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