graft-versus-host disease

noun

Definition of graft-versus-host disease

: a potentially fatal bodily condition that results when T cells from a tissue or organ transplant and especially a bone marrow transplant react immunologically against the recipient's antigens attacking cells and tissues

Examples of graft-versus-host disease in a Sentence

Recent Examples on the Web In such cases, ruxolitinib has proved successful in interrupting the chain of events that leads graft-versus-host disease to develop into a cytokine storm. Mark Johnson, Milwaukee Journal Sentinel, "UW joins drug trial aimed at preventing major COVID-19 killer: Haywire immune response," 24 June 2020 There are other treatments used to prevent a cytokine storm in patients suffering from graft-versus-host disease. Mark Johnson, Milwaukee Journal Sentinel, "UW joins drug trial aimed at preventing major COVID-19 killer: Haywire immune response," 24 June 2020 These patients develop a complication called graft-versus-host disease, in which the donor marrow mistakes the patient's own cells for foreign invaders, and attacks them. Mark Johnson, Milwaukee Journal Sentinel, "UW joins drug trial aimed at preventing major COVID-19 killer: Haywire immune response," 24 June 2020 Beyond that, there are dozens of ongoing clinical trials for conditions ranging from schizophrenia to Crohn’s disease to graft-versus-host disease—not to mention the appearance of CBD in consumer products ranging from oils to coffee to tampons. Amber Dance, Scientific American, "As CBD Skyrockets in Popularity, Scientists Scramble to Understand How It’s Metabolized," 14 Nov. 2019 But twice her body was attacked by graft-versus-host disease; her donor stem cells rejected by her body. Dana Hunsinger Benbow, Indianapolis Star, "Colts' Pierre Desir, Kenny Moore help pay for teen volleyball player's funeral," 18 July 2019 Donor stem cells can go on the attack post-transplant, a condition known as graft-versus-host disease. Terry Tang, The Seattle Times, "Stem cell transplant cements Arizona men’s father-son bond," 10 Sep. 2018 Unfortunately, the transplant triggered a rare form of chronic graft-versus-host disease, in which the donor's immune cells attack the recipient's normal cells. Sandee Lamotte, CNN, "Dogs bring 'a little light' into 'nightmare' of childhood cancer," 22 Dec. 2017

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'graft-versus-host disease.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of graft-versus-host disease

1965, in the meaning defined above

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The first known use of graft-versus-host disease was in 1965

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Cite this Entry

“Graft-versus-host disease.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/graft-versus-host%20disease. Accessed 23 Nov. 2020.

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More Definitions for graft-versus-host disease

graft-versus-host disease

noun

Medical Definition of graft-versus-host disease

: a bodily condition that results when T cells from a usually allogeneic tissue or organ transplant and especially a bone marrow transplant react immunologically against the recipient's antigens attacking cells and tissues, that affects especially the skin, gastrointestinal tract, and liver with symptoms including skin rash, fever, diarrhea, liver dysfunction, abdominal pain, and anorexia, and that may be fatal abbreviation GVHD

called also graft-versus-host reaction

More from Merriam-Webster on graft-versus-host disease

Britannica.com: Encyclopedia article about graft-versus-host disease

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