Canavan disease

noun
Can·​a·​van disease | \ ˈka-nə-ˌvan- How to pronounce Canavan disease (audio) \
variants: or less commonly Canavan's disease \ ˈka-​nə-​ˌvanz-​ How to pronounce Canavan's disease (audio) \

Definition of Canavan disease

: a rare, usually fatal, demyelinating disease of infancy that is characterized by spongy degeneration of the brain caused by an enzyme deficiency and that typically affects individuals of eastern European Jewish ancestry … was diagnosed before he turned 5 months old with Canavan disease—a rare neurological disorder in which genes don't produce the protective myelin in the brain, causing the brain's white matter to degenerate into spongy tissue riddled with microscopic fluid-filled spaces.— Burt Constable

Note: Canavan disease is inherited as an autosomal recessive trait requiring that both parents pass on a copy of the defective gene on a chromosome other than a sex chromosome.

First Known Use of Canavan disease

1965, in the meaning defined above

History and Etymology for Canavan disease

after Myrtelle May Canavan †1953 U.S. pathologist

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The first known use of Canavan disease was in 1965

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More Definitions for Canavan disease

Canavan disease

noun
Can·​a·​van disease | \ ˈkan-ə-ˌvan- How to pronounce Canavan disease (audio) \
variants: also Canavan's disease \ -​ˌvanz-​ How to pronounce Canavan's disease (audio) \

Medical Definition of Canavan disease

: a rare usually fatal demyelinating disease of infancy that is characterized by spongy degeneration of the brain caused by an enzyme deficiency inherited as an autosomal recessive trait and that typically affects individuals of eastern European Jewish ancestry

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