unhinge

1 to cause to go insane or as if insane the endless harassment by the guards completely unhinged the prisoners of war Synonyms crack, derange, frenzy, loco, madden, unbalance, craze, unstringRelated Words agitate, bother, confuse, discompose, disquiet, distract, disturb, perturb, unsettle, upset; annoy, irritate, vexNear Antonyms calm, quiet, relax, settle, soothe, tranquilize (also tranquillize)

2 to trouble the mind of; to make uneasy I was momentarily unhinged by the unexpected question Synonyms agitate, ail, alarm (also alarum), bother, concern, derail, discomfort, discompose, dismay, disquiet, distemper, distract, distress, exercise, flurry, frazzle, freak (out), fuss, hagride, perturb, undo, disturb, unsettle, upset, weird out, worryRelated Words aggravate, anger, annoy, bug, chafe, chivy (or chivvy), exasperate, fret, gall, get, grate, harass, harry, irk, irritate, nettle, peeve, pester, pique, put off, put out, rile, vex; bedevil, haunt, plague; abash, confound, confuse, discomfit, disconcert, discountenance, embarrass, faze, fluster, jar, mortify, nonplus, rattle, shake up; daunt, demoralize, discourage, dishearten, dispirit, unnerveNear Antonyms allay, alleviate, assuage; appease, conciliate, mollify, pacify, placate, propitiateAntonyms calm, compose, quiet, settle, soothe, tranquilize (also tranquillize)