disease

noun

dis·​ease di-ˈzēz How to pronounce disease (audio)
Synonyms of diseasenext
1
: a condition of the living animal or plant body or of one of its parts that impairs normal functioning and is typically manifested by distinguishing signs and symptoms : sickness, malady
infectious diseases
a rare genetic disease
heart disease
2
: a harmful development (as in a social institution)
sees the city's crime as a disease
3
obsolete : trouble

Examples of disease in a Sentence

He suffers from a rare genetic disease. a disease of the mind Thousands die of heart disease each year. They are working to stop the spread of disease in rural areas. The article cites intolerance as one of the most dangerous of society's diseases. He sees crime as a disease that too often plagues the poor and disadvantaged.
Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Fox, 64, has worked for decades with Parkinson’s disease, which he was diagnosed with at age 29 in the early 1990s but kept private until 1998. Theresa Braine, New York Daily News, 9 Apr. 2026 Fox plays Gerry on the show, a Parkinson’s patient who bonds with Ford’s character Paul, who is also diagnosed with Parkinson’s disease. Alex Cramer, HollywoodReporter, 8 Apr. 2026 Paul, of course, continues to face the reality of his Parkinson’s disease — and that will remain an important part of that character’s journey. Michael Schneider, Variety, 8 Apr. 2026 Diets high in sodium are known to cause an increase in blood pressure, which also raises the risk of heart disease, gastric cancer, obesity, osteoporosis and kidney disease, according to the World Health Organization. Angelica Stabile, FOXNews.com, 8 Apr. 2026 See All Example Sentences for disease

Word History

Etymology

Middle English disese, from Anglo-French desease, desaise, from des- dis- + eise ease

First Known Use

14th century, in the meaning defined at sense 3

Time Traveler
The first known use of disease was in the 14th century

Browse Nearby Words

Cite this Entry

“Disease.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/disease. Accessed 11 Apr. 2026.

Kids Definition

disease

noun
dis·​ease diz-ˈēz How to pronounce disease (audio)
: an abnormal bodily condition of a living plant or animal that interferes with functioning and can usually be recognized by signs and symptoms : illness
diseased adjective

Medical Definition

disease

noun
dis·​ease diz-ˈēz How to pronounce disease (audio)
: an impairment of the normal state of the living animal or plant body or one of its parts that interrupts or modifies the performance of the vital functions, is typically manifested by distinguishing signs and symptoms, and is a response to environmental factors (as malnutrition, industrial hazards, or climate), to specific infective agents (as worms, bacteria, or viruses), to inherent defects of the organism (as genetic anomalies), or to combinations of these factors : sickness, illness

called also morbus

compare health sense 1
diseased adjective

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