disease

noun

dis·​ease di-ˈzēz How to pronounce disease (audio)
Synonyms of diseasenext
1
: a condition of the living animal or plant body or of one of its parts that impairs normal functioning and is typically manifested by distinguishing signs and symptoms : sickness, malady
infectious diseases
a rare genetic disease
heart disease
2
: a harmful development (as in a social institution)
sees the city's crime as a disease
3
obsolete : trouble

Examples of disease in a Sentence

He suffers from a rare genetic disease. a disease of the mind Thousands die of heart disease each year. They are working to stop the spread of disease in rural areas. The article cites intolerance as one of the most dangerous of society's diseases. He sees crime as a disease that too often plagues the poor and disadvantaged.
Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
That means a large number of school-age children skipped their vaccinations in the same year that the measles outbreak in West Texas claimed the lives of two children who were not vaccinated against the disease. Lauren Mascarenhas, CNN Money, 19 Feb. 2026 Harm reduction can encompass a range of practices, including handing out free needles to slow the spread of disease, and many local leaders credit some of those efforts with recent drops in fatal overdoses. Blake Nelson, San Diego Union-Tribune, 19 Feb. 2026 Vaccines that use mRNA are attractive prospects for protecting against flu and a host of other diseases, including cancer. Claire Cameron, Scientific American, 18 Feb. 2026 The actress will next get a PET scan, a nuclear imaging test that helps detect diseases like cancer at a cellular level. Arushi Jacob, Variety, 18 Feb. 2026 See All Example Sentences for disease

Word History

Etymology

Middle English disese, from Anglo-French desease, desaise, from des- dis- + eise ease

First Known Use

14th century, in the meaning defined at sense 3

Time Traveler
The first known use of disease was in the 14th century

Browse Nearby Words

Cite this Entry

“Disease.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/disease. Accessed 21 Feb. 2026.

Kids Definition

disease

noun
dis·​ease diz-ˈēz How to pronounce disease (audio)
: an abnormal bodily condition of a living plant or animal that interferes with functioning and can usually be recognized by signs and symptoms : illness
diseased adjective

Medical Definition

disease

noun
dis·​ease diz-ˈēz How to pronounce disease (audio)
: an impairment of the normal state of the living animal or plant body or one of its parts that interrupts or modifies the performance of the vital functions, is typically manifested by distinguishing signs and symptoms, and is a response to environmental factors (as malnutrition, industrial hazards, or climate), to specific infective agents (as worms, bacteria, or viruses), to inherent defects of the organism (as genetic anomalies), or to combinations of these factors : sickness, illness

called also morbus

compare health sense 1
diseased adjective

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