affliction

discomfort

cross, crucible, trial

heartache, heartbreak, joylessness, sadness, sorrow, unhappiness

emergency, pinch

asperity, difficulty, hardship, rigor

ache, pang, smarting, soreness, stitch, throe, twinge

danger, jeopardy, trouble

agony, distress, pain, suffering, torment

blue devils, blues, dejection, depression, desolateness, desolation, despair, despondence, despondency, disconsolateness, dispiritedness, distress, doldrums, downheartedness, dreariness, dumps, forlornness, gloom, gloominess, glumness, heartsickness, joylessness, melancholy, miserableness, misery, mopes, oppression, sorrowfulness, unhappiness, woefulness, wretchedness

contrition, guilt, regret, remorse, rue, self-reproach, shame

melancholia, self-pity

hex, hoodoo, jinx

danger, hazard, menace, peril, risk, threat, trouble

booby trap, catch, pitfall, snag

bête noire, bogey (also bogie), bugaboo, bugbear, hobgoblin, ogre

disservice, injustice, outrage, wrong

affront, dart, indignity, insult, offense (or offence)

beating, crippling, mayhem, mutilation

defacement, disability, disablement, disfigurement, impairment

lesion

rupture, strain

abrasion, chafe, scrape, scratch

boo-boo, bruise, contusion, swelling, wound

bump, concussion

cut, gash, laceration

burn, scald, scar, scathe, sear