Synonyms of breakthrough

breakthrough

noun

ˈbrāk-ˌthrü 

as in improvement

an instance of notable progress in the development of knowledge, technology, or skill

Alexander Fleming's discovery of penicillin was one of medicine's great breakthroughs, for penicillin became the first antibiotic to successfully combat bacterial infections in humans

Synonyms & Similar Words

• improvement
• advance
• advancement
• enhancement
• development
• innovation
• discovery
• refinement
• evolution
• increase
• upturn
• upswing
• revival
• amelioration
• strengthening
• maturation
• enlightenment
• growth
• betterment
• find
• renaissance
• education
• boost
• expansion
• quantum leap
• uplift
• windfall
• gestation
• ripening
• elaboration
• civilization
• melioration
• upgrade
• perfection
• heightening
• edification
• uptrend
• renascence
• invention

Antonyms & Near Antonyms

• setback
• breakdown
• collapse
• crash
• reduction
• impediment
• hindrance
• decrease
• failing
• decline
• deterioration
• stumbling block
• worsening
• lapse
• weakening
• decay
• degeneration
• sinking
• impairment
• descent
• drawback
• shortcoming
• slowing
• lessening
• decadence
• downgrade
• detriment
• glitch
• declension
• diminishment
• disablement
• flagging
• languishment
• ebbing

Example Sentences

Recent Examples of breakthrough

Cancer vaccine breakthrough Shares in Moderna soared over 170% in Wednesday’s session, while Merck rallied over 10% after the pharmaceutical groups announced positive initial results from an experimental cancer vaccine. — Leonie Kidd, CNBC, 20 Aug. 2026

Their results recently published in the journal Physical Review Letters signal a major breakthrough in quantum physics—one that indicates a primordial quark-gluon plasma soup is actually possible with lighter ingredients. — Andrew Paul, Popular Science, 20 Aug. 2026

For plenty of programs, seven wins and a playoff appearance would constitute a breakthrough. — Miami Herald, 20 Aug. 2026

San Jose, which is 0-4-1 since July 1, tried to find the breakthrough while the Galaxy was down to 10 men. — Mercury News, 20 Aug. 2026