breakthrough

an instance of notable progress in the development of knowledge, technology, or skill Alexander Fleming's discovery of penicillin was one of medicine's great breakthroughs, for penicillin became the first antibiotic to successfully combat bacterial infections in humans Synonyms advancement, advance, enhancement, improvement, refinementRelated Words quantum leap; amelioration, boost, heightening, increase, melioration, strengthening, upgrade, uplift, upswing, uptrend, upturn; betterment, development, elaboration, evolution, expansion, gestation, growth, maturation, perfection, ripening; civilization, edification, education, enlightenment; renaissance, renascence, revival; discovery, find, windfall; innovation, inventionNear Antonyms breakdown, collapse, crash; hindrance, impediment, stumbling block; decadence, decay, declension, decline, decrease, degeneration, descent, deterioration, diminishment, downgrade, ebbing, failing, flagging, languishment, lapse, lessening, reduction, sinking, slowing, weakening, worsening; detriment, disablement, drawback, glitch, impairment, shortcomingAntonyms setback