Synonyms and Antonyms of breakthrough
- Alexander Fleming's discovery of penicillin was one of medicine's great breakthroughs, for penicillin became the first antibiotic to successfully combat bacterial infections in humans.
decadence, decay, decline, decrease, degeneration, descent, deterioration, diminishment, downgrade, ebbing, failing, flagging, languishment, lapse, lessening, reduction, sinking, slowing, weakening, worsening
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