break·through
ˈbrāk-ˌthrü 
plural breakthroughs
1
a
: a sudden advance especially in knowledge or technique
a medical breakthrough
b
: a person's first notable success
—often used before another noun
a breakthrough novel
the actress's breakthrough performance
2
a
: an act or instance of moving through or beyond an obstacle
a breakthrough in the talks between the region's leaders
a breakthrough agreement
b
: an instance of passing through a barrier or protection
The ice under the surface begins to deteriorate, increasing the risk of breakthroughs.—
Vicki Winger
Vicki Winger
specifically, medical
: infection occurring in someone who is fully vaccinated against an infectious agent
A vaccine breakthrough occurs when a person tests positive for COVID-19 two weeks after being fully vaccinated against the disease … —David Rasbach
—often used before another noun David Rasbach Two other CDC studies of breakthrough cases at nursing homes showed the vaccines protected residents, even when the virus spread through the homes. —Maura Dolan
Maura Dolan … the academy recently recommended that children receive two doses of the chicken pox vaccine, rather than just one, because the additional dose bolsters immunity and may help reduce breakthrough infection. —Maria Raven
Maria Raven 3
warfare
: an offensive military assault that penetrates and carries beyond a defensive line
broke through; broken through; breaking through; breaks through
: to make a breakthrough
Examples of breakthrough in a Sentence
Noun
Researchers say they have made a major breakthrough in cancer treatment.
The police have announced a breakthrough in the murder case.
This job could be the breakthrough she's been waiting for.
Recent Examples on the Web
Deepa Nagraj, Forbes.com, 7 July 2025
Creative breakthroughs are on the horizon, Aquarius.
—Valerie Mesa, People.com, 7 July 2025
Rhonda Richford, Footwear News, 4 July 2025
When the duo broke through in 2009, American and North American style dubstep was beginning its moment of ubiquity, as artists like Skrillex and Excison delivered sharp, heavy iterations of the U.K.-born sound and countless DJs became a drop jockeys trying to out-pummel the last.
—Katie Bain, Billboard, 3 July 2025
See All Example Sentences for breakthrough
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Noun
However, these breakthroughs come with complex environmental, social and governance (ESG) implications that cannot be overlooked.
—Deepa Nagraj, Forbes.com, 7 July 2025
Creative breakthroughs are on the horizon, Aquarius.
—Valerie Mesa, People.com, 7 July 2025
Verb
Reflecting on Run, WSN’s concept to connect buyers with emerging designers in a showroom and runway space held during fashion week in March, Maus acknowledged the challenges of breaking through in the current market.
—Rhonda Richford, Footwear News, 4 July 2025
When the duo broke through in 2009, American and North American style dubstep was beginning its moment of ubiquity, as artists like Skrillex and Excison delivered sharp, heavy iterations of the U.K.-born sound and countless DJs became a drop jockeys trying to out-pummel the last.
—Katie Bain, Billboard, 3 July 2025
See All Example Sentences for breakthrough
Cite this Entry
“Breakthrough.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/breakthrough. Accessed 11 Jul. 2025.
Copy CitationKids Definition
breakthrough
noun
break·through
ˈbrāk-ˌthrü
: a sudden advance in knowledge or technique
a breakthrough in medical science
Medical Definition
breakthrough
noun
break·through
ˈbrāk-ˌthrü
: infection occurring in someone who is fully vaccinated against an infectious agent
—often used before another noun
breakthrough infections
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