mutation

noun
mu·​ta·​tion | \ myü-ˈtā-shən How to pronounce mutation (audio) \

Definition of mutation

1 : a significant and basic alteration : change
2 : umlaut
3a : a relatively permanent change in hereditary material that involves either a change in chromosome structure or number (as in translocation, deletion, duplication, or polyploidy) or a change in the nucleotide sequence of a gene's codons (as in frameshift or missense errors) and that occurs either in germ cells or in somatic cells but with only those in germ cells being capable of perpetuation by sexual reproduction Mutations known to cause disease have been identified in approximately 1000 genes.— Alan E. Guttmacher and Francis S. Collins also : the process of producing a mutation Microorganisms have been used extensively to study mutation— George A. Wistreich et al.
b : an individual, strain, or trait resulting from mutation The worst E. coli bacterium, E. coli 0157:H, a mutation discovered in 1982 that has at least sixty-two subtypes, causes hemorrhagic colitis …— Wayne Biddle

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Other Words from mutation

mutational \ myü-​ˈtā-​shnəl How to pronounce mutational (audio) , -​shə-​nᵊl \ adjective
mutationally adverb

Examples of mutation in a Sentence

The cat's short tail is the result of mutation. The condition is caused by a genetic mutation. The cat's short tail is the result of a mutation. The building is a mutation of the original design.
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Recent Examples on the Web

An all-out war looms when the discovery of a cure for mutations draws a line between the followers of Charles Xavier and those of Magneto. Los Angeles Times, "Movies on TV this week Sept. 15, 2019: ‘Alien,’ ‘Aliens’ and more," 13 Sep. 2019 By identifying cells that developed resistance to the drug, known as OTS964, and sequencing them for mutations that confer that trait, the lab showed the drug instead blocks the protein CDK11, which plays a different role in cell proliferation. Jocelyn Kaiser, Science | AAAS, "Some cancer drugs miss their target. CRISPR could improve their aim," 11 Sep. 2019 Strauss will soon receive a second round of custom vaccine doses engineered to target a common mutation in her tumors. San Diego Union-Tribune, "UCSD’s cancer vaccine trial shows range of results at the one-year mark," 3 Sep. 2019 Women with positive results on the primary care risk assessment are then recommended to receive genetic counseling and possibly genetic testing for the mutations. Jacqueline Howard, CNN, "More women should be assessed for BRCA mutations, new recommendations say," 20 Aug. 2019 Richmond said the two tests involved in the scams are: CGx, which tests for genetic predisposition to cancer, and PGx, a pharmacogenomic test for genetic mutations that affect how the body handles certain medications. Kaiser Health News, oregonlive.com, "Watch out for this Medicare scam involving DNA genetic tests," 3 Aug. 2019 Richmond said the two tests involved in the scams are: CGx, which tests for genetic predisposition to cancer, and PGx, a pharmacogenomic test for genetic mutations that affect how the body handles certain medications. NBC News, "Genetic-testing scam targets seniors and rips off Medicare," 31 July 2019 Zolgensma was approved by the U.S. Food and Drug Administration to treat children with spinal muscular atrophy (SMA), a rare and often fatal disease caused by mutations in the SMN1 gene. Kaleigh Fasanella, Allure, "Why This Life-Saving Drug Costs $2.1 Million, and Why Insurers Won't Cover It," 30 July 2019 Advances in epilepsy treatment Advances in genetic testing technology have allowed for more genetic mutations to be identified in children with epilepsy. Isabel Derera, The Conversation, "CBD and genetic testing provide hope for ‘intractable’ epilepsy in children," 25 July 2019

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'mutation.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of mutation

14th century, in the meaning defined at sense 1

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Statistics for mutation

Last Updated

22 Sep 2019

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Time Traveler for mutation

The first known use of mutation was in the 14th century

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More Definitions for mutation

mutation

noun
mu·​ta·​tion | \ myü-ˈtā-shən How to pronounce mutation (audio) \

Kids Definition of mutation

: a change in a gene or the resulting new trait it produces in an individual

mutation

noun
mu·​ta·​tion | \ myü-ˈtā-shən How to pronounce mutation (audio) \

Medical Definition of mutation

1 : a relatively permanent change in hereditary material that involves either a change in chromosome structure or number (as in translocation, deletion, duplication, or polyploidy) or a change in the nucleotide sequence of a gene's codons (as in frameshift or missense errors) and occurs either in germ cells or in somatic cells but with only those in germ cells being capable of perpetuation by sexual reproduction also : the process of producing a mutation
2 : an individual, strain, or trait resulting from mutation

Other Words from mutation

mutational \ -​shnəl, -​shən-​ᵊl How to pronounce mutational (audio) \ adjective
mutationally \ -​ē How to pronounce mutationally (audio) \ adverb

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Comments on mutation

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