mutation

noun
mu·​ta·​tion | \ myü-ˈtā-shən How to pronounce mutation (audio) \

Definition of mutation

1 : a significant and basic alteration : change
2 : umlaut
3a : a relatively permanent change in hereditary material that involves either a change in chromosome structure or number (as in translocation, deletion, duplication, or polyploidy) or a change in the nucleotide sequence of a gene's codons (as in frameshift or missense errors) and that occurs either in germ cells or in somatic cells but with only those in germ cells being capable of perpetuation by sexual reproduction Mutations known to cause disease have been identified in approximately 1000 genes.— Alan E. Guttmacher and Francis S. Collins also : the process of producing a mutation Microorganisms have been used extensively to study mutation— George A. Wistreich et al.
b : an individual, strain, or trait resulting from mutation The worst E. coli bacterium, E. coli 0157:H, a mutation discovered in 1982 that has at least sixty-two subtypes, causes hemorrhagic colitis …— Wayne Biddle

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Other Words from mutation

mutational \ myü-​ˈtā-​shnəl How to pronounce mutational (audio) , -​shə-​nᵊl \ adjective
mutationally adverb

Examples of mutation in a Sentence

The cat's short tail is the result of mutation. The condition is caused by a genetic mutation. The cat's short tail is the result of a mutation. The building is a mutation of the original design.
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Recent Examples on the Web But the mutation causes hemoglobin to aggregate into rock-hard rods that give cells a sickle shape. Meredith Wadman, Science | AAAS, "A new sickle cell drug could soon get U.S. approval. But does it work?," 17 Sep. 2019 Some are inherited, while others occur as new mutations. Author: Ariana Eunjung Cha, Anchorage Daily News, "The autistic children of sperm donor H898," 16 Sep. 2019 Two men, known as the Berlin patient and the London patient, became the first people in the world to be cured of HIV after receiving bone marrow transplants from donors who had the mutation naturally. Serenitie Wang, CNN, "Chinese scientists use CRISPR tool on HIV patient for the first time," 13 Sep. 2019 In donated human brains, his team found more tau tangles clustered around amyloid plaques when people harbored microglia-weakening TREM2 mutations. Lauran Neergaard, chicagotribune.com, "Scientists rethink Alzheimer’s, diversifying the drug search," 11 Sep. 2019 The gene is later inserted into the genome and essentially corrects the mutation without replacing the entire gene. Fox News, "New gene-editing technology could help treat Huntington's disease, premature aging, study says," 29 Aug. 2019 Repotrectinib is intended to inhibit mutations that drive non-small cell lung cancer and advanced solid tumors, both difficult to treat malignancies. San Diego Union-Tribune, "Turning Point Therapeutics raises $202 million for cancer therapy," 17 Sep. 2019 Some are inherited, while others occur as new mutations. Author: Ariana Eunjung Cha, Anchorage Daily News, "The autistic children of sperm donor H898," 16 Sep. 2019 Some are inherited, while others occur as new mutations. oregonlive, "Mom sues, saying prolific sperm donor passed along autism," 15 Sep. 2019

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'mutation.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of mutation

14th century, in the meaning defined at sense 1

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Statistics for mutation

Last Updated

20 Oct 2019

Time Traveler for mutation

The first known use of mutation was in the 14th century

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More Definitions for mutation

mutation

noun
mu·​ta·​tion | \ myü-ˈtā-shən How to pronounce mutation (audio) \

Kids Definition of mutation

: a change in a gene or the resulting new trait it produces in an individual

mutation

noun
mu·​ta·​tion | \ myü-ˈtā-shən How to pronounce mutation (audio) \

Medical Definition of mutation

1 : a relatively permanent change in hereditary material that involves either a change in chromosome structure or number (as in translocation, deletion, duplication, or polyploidy) or a change in the nucleotide sequence of a gene's codons (as in frameshift or missense errors) and occurs either in germ cells or in somatic cells but with only those in germ cells being capable of perpetuation by sexual reproduction also : the process of producing a mutation
2 : an individual, strain, or trait resulting from mutation

Other Words from mutation

mutational \ -​shnəl, -​shən-​ᵊl How to pronounce mutational (audio) \ adjective
mutationally \ -​ē How to pronounce mutationally (audio) \ adverb

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