: a significant and basic alteration : change
: a relatively permanent change in hereditary material that involves either a change in chromosome structure or number (as in translocation, deletion, duplication, or polyploidy) or a change in the nucleotide sequence of a gene's codons (as in frameshift or missense errors) and that occurs either in germ cells or in somatic cells but with only those in germ cells being capable of perpetuation by sexual reproduction
: the process of producing a mutation
- Mutations known to cause disease have been identified in approximately 1000 genes.
- —Alan E. Guttmacher and Francis S. Collins
- Microorganisms have been used extensively to study mutation …
- —George A. Wistreich et al.
: an individual, strain, or trait resulting from mutation
- The worst E. coli bacterium, E. coli 0157:H, a mutation discovered in 1982 that has at least sixty-two subtypes, causes hemorrhagic colitis …
- —Wayne Biddle