genetic mutation

noun

plural genetic mutations

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Lacking working copies of the p53 gene, cells can begin to divide without check, though several other genetic mutations are thought to be needed to foster a full-blown malignancy.

—Natalie Angier

Examples of genetic mutation in a Sentence

Recent Examples on the Web

According to the new paper, a genetic mutation in our ancient ancestors is to thank for our lack of tail. —Sam Walters, Discover Magazine, 4 Mar. 2024

Down syndrome occurs when a genetic mutation causes two copies of chromosome 21 to form, resulting in physical and developmental changes, the study authors said in a Feb. 20 statement. —Irene Wright, Miami Herald, 20 Feb. 2024

Patients either get the disorder from their parents or a random genetic mutation. —Vanessa Etienne, Peoplemag, 22 Jan. 2024

Still, 30% of diagnoses for those under the age of 50 are related not to outside exposures, but rather to an underlying family history or genetic mutation, putting them more at risk, according to the American Cancer Society. —Dr. Aishwarya Thakur, ABC News, 17 Jan. 2024

While the current trials are for a rare type of deafness, researchers with the companies think other genetic mutations that cause deafness could be addressed with gene therapy. —WIRED, 20 Oct. 2023

When cancer is found at a younger-than-usual age, doctors usually suspect that genetic mutations may be to blame. —Knvul Sheikh, New York Times, 27 Mar. 2024

Its horrific impact on people raises a question: How has this genetic mutation persisted for 7,300 years? —Robert Pearl, Forbes, 28 Feb. 2024

Lunella’s world is full of grit and wonder, and in the show, her superpowers aren’t the result of some mysterious genetic mutation but rather a product of her wild intelligence, supreme curiosity, and supportive community. —Vulture, 2 Feb. 2024

Word History

First Known Use

1915, in the meaning defined above

Medical Definition

genetic mutation

noun

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Gaucher's disease results from one of many genetic mutations that can either slow or prevent the breakdown of certain glycolipids, which accumulate in storage vesicles and eventually kill cells.

—Joseph Alper