genetic mutation
noun
plural genetic mutations
: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes
Lacking working copies of the p53 gene, cells can begin to divide without check, though several other genetic mutations are thought to be needed to foster a full-blown malignancy.—
Natalie Angier
Natalie AngierExamples of genetic mutation in a Sentence
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Advertisement Advertisement In the latest case, the scientists developed a CRISPR treatment for a boy named KJ, who was born with genetic mutations in his liver cells that prevent him from breaking down proteins properly.
—Alice Park, Time, 15 May 2025
Piedrahita eventually became a neurology nurse, caring for families, including his own, who were marked by a rare genetic mutation linked to early-onset Alzheimer’s disease.
—Marion Renault, The Atlantic, 13 May 2025
The National Breast Cancer Foundation reports that women with these specific genetic mutations have a much higher lifetime risk of the disease.
—Taylor Lane, Flow Space, 8 May 2025
But her case is caused by a rare genetic mutation, so medications that work for 90% of people with cystic fibrosis won’t help her.
—Laura Ungar, Los Angeles Times, 30 Apr. 2025
See All Example Sentences for genetic mutation
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Alice Park, Time, 15 May 2025
Piedrahita eventually became a neurology nurse, caring for families, including his own, who were marked by a rare genetic mutation linked to early-onset Alzheimer’s disease.
—Marion Renault, The Atlantic, 13 May 2025
The National Breast Cancer Foundation reports that women with these specific genetic mutations have a much higher lifetime risk of the disease.
—Taylor Lane, Flow Space, 8 May 2025
But her case is caused by a rare genetic mutation, so medications that work for 90% of people with cystic fibrosis won’t help her.
—Laura Ungar, Los Angeles Times, 30 Apr. 2025
See All Example Sentences for genetic mutation
Cite this Entry
“Genetic mutation.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/genetic%20mutation. Accessed 21 May. 2025.
Copy CitationMedical Definition
genetic mutation
noun
: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes
Gaucher's disease results from one of many genetic mutations that can either slow or prevent the breakdown of certain glycolipids, which accumulate in storage vesicles and eventually kill cells.—Joseph Alper
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