genetic mutation


plural genetic mutations
: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes
Lacking working copies of the p53 gene, cells can begin to divide without check, though several other genetic mutations are thought to be needed to foster a full-blown malignancy.Natalie Angier

Examples of genetic mutation in a Sentence

Recent Examples on the Web This injectable drug was approved by the FDA in 2022, not as a general weight-loss drug, but for the treatment of severe obesity caused by a genetic mutation. Stephen C. George, Discover Magazine, 30 Apr. 2024 World's Only All-White Panda Captured on Video in Rare Sighting Albinism is a genetic mutation that causes cells not to produce melanin. Kelli Bender, Peoplemag, 1 May 2024 There are about 150 possible genetic mutations that may cause type 2 diabetes. Barbie Cervoni, Health, 2 Apr. 2024 According to the new paper, a genetic mutation in our ancient ancestors is to thank for our lack of tail. Sam Walters, Discover Magazine, 4 Mar. 2024 Down syndrome occurs when a genetic mutation causes two copies of chromosome 21 to form, resulting in physical and developmental changes, the study authors said in a Feb. 20 statement. Irene Wright, Miami Herald, 20 Feb. 2024 Patients either get the disorder from their parents or a random genetic mutation. Vanessa Etienne, Peoplemag, 22 Jan. 2024 Still, 30% of diagnoses for those under the age of 50 are related not to outside exposures, but rather to an underlying family history or genetic mutation, putting them more at risk, according to the American Cancer Society. Dr. Aishwarya Thakur, ABC News, 17 Jan. 2024 While the current trials are for a rare type of deafness, researchers with the companies think other genetic mutations that cause deafness could be addressed with gene therapy. WIRED, 20 Oct. 2023

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'genetic mutation.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

First Known Use

1915, in the meaning defined above

Time Traveler
The first known use of genetic mutation was in 1915

Dictionary Entries Near genetic mutation

Cite this Entry

“Genetic mutation.” Dictionary, Merriam-Webster, Accessed 21 May. 2024.

Medical Definition

genetic mutation

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes
Gaucher's disease results from one of many genetic mutations that can either slow or prevent the breakdown of certain glycolipids, which accumulate in storage vesicles and eventually kill cells.Joseph Alper
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