genetic mutation

noun

plural genetic mutations

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Lacking working copies of the p53 gene, cells can begin to divide without check, though several other genetic mutations are thought to be needed to foster a full-blown malignancy.

—Natalie Angier

Examples of genetic mutation in a Sentence

Recent Examples on the Web

Common causes of mitochondrial dysfunction include genetic mutation, reactive oxygen species (ROS), neuroinflammation, epigenetic changes, and environmental factors. —New Atlas, 8 Aug. 2025

The trial is testing the vaccine in women who are currently cancer-free but considered high-risk due to genetic mutations (like BRCA1/2) or family history. —Lauryn Higgins, Flow Space, 29 July 2025

These cancers are increasingly drawing the attention of researchers like Dr. Landi, who are studying the role that environmental exposures, genetic mutations or other risk factors might play. —Nina Agrawal, New York Times, 22 July 2025

The genetic mutations that the patients of both Waxman and Woods had affect a sodium channel called NaV1.7, which is predominantly found in peripheral pain-sensing neurons. —Rivka Galchen, New Yorker, 26 May 2025

Word History

First Known Use

1915, in the meaning defined above

Rhymes for genetic mutation

• acclimatisation
• acclimatization
• acidification
• actualization
• annualization
• autocorrelation
• autoregulation
• beatification
• beneficiation
• biodegradation
• biotransformation
• bureaucratization

Medical Definition

genetic mutation

noun

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Gaucher's disease results from one of many genetic mutations that can either slow or prevent the breakdown of certain glycolipids, which accumulate in storage vesicles and eventually kill cells.

—Joseph Alper