genetic mutation

noun

plural genetic mutations

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Lacking working copies of the p53 gene, cells can begin to divide without check, though several other genetic mutations are thought to be needed to foster a full-blown malignancy.

—Natalie Angier

Examples of genetic mutation in a Sentence

Recent Examples on the Web

Elements that increase risk include a history of radiation to the chest, certain genetic mutations, and having a first-degree relative (like a mother or sister) with breast cancer. —Katia Hetter, CNN Money, 1 Oct. 2025

While learning about possible genetic mutations can be upsetting, both Aliabadi and Goldfarb emphasized that this knowledge means power and future safety and health. —Helen Carefoot, Flow Space, 1 Oct. 2025

Some research suggests that females might be protected from certain harmful genetic mutations because of the two X chromosomes. —Laura Baisas, Popular Science, 1 Oct. 2025

Although the cause of Huntington’s is a simple genetic mutation, preventing that mutation from resulting in disease is a challenge. —Allison Parshall, Scientific American, 30 Sep. 2025

Word History

First Known Use

1915, in the meaning defined above

Rhymes for genetic mutation

• acclimatisation
• acclimatization
• acidification
• actualization
• annualization
• autocorrelation
• autoregulation
• beatification
• beneficiation
• biodegradation
• biotransformation
• bureaucratization

Medical Definition

genetic mutation

noun

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Gaucher's disease results from one of many genetic mutations that can either slow or prevent the breakdown of certain glycolipids, which accumulate in storage vesicles and eventually kill cells.

—Joseph Alper