genetic mutation

noun

plural genetic mutations

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Lacking working copies of the p53 gene, cells can begin to divide without check, though several other genetic mutations are thought to be needed to foster a full-blown malignancy.

—Natalie Angier

Examples of genetic mutation in a Sentence

Recent Examples on the Web

While the condition isn't genetic – we're not born with genetic mutations for it – in recent years scientists have gained greater knowledge of it having an epigenetic basis. —New Atlas, 7 Oct. 2025

That’s why two people with the same genetic mutation can seem so different. —Santhosh Girirajan, The Conversation, 7 Oct. 2025

Elements that increase risk include a history of radiation to the chest, certain genetic mutations, and having a first-degree relative (like a mother or sister) with breast cancer. —Katia Hetter, CNN Money, 1 Oct. 2025

While learning about possible genetic mutations can be upsetting, both Aliabadi and Goldfarb emphasized that this knowledge means power and future safety and health. —Helen Carefoot, Flow Space, 1 Oct. 2025

Word History

First Known Use

1915, in the meaning defined above

Rhymes for genetic mutation

• acclimatisation
• acclimatization
• acidification
• actualization
• annualization
• autocorrelation
• autoregulation
• beatification
• beneficiation
• biodegradation
• biotransformation
• bureaucratization

Medical Definition

genetic mutation

noun

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Gaucher's disease results from one of many genetic mutations that can either slow or prevent the breakdown of certain glycolipids, which accumulate in storage vesicles and eventually kill cells.

—Joseph Alper