gene mutation

noun
plural gene mutations

Definition of gene mutation

: a permanent alteration (as by point mutation or frameshift mutation) in the nucleotide sequence of a gene Researchers have identified a gene mutation that's believed to predispose people to malignant melanoma, the deadliest and most aggressive type of skin cancer.Health News — compare point mutation

Examples of gene mutation in a Sentence

Recent Examples on the Web Twin sisters Norma Lawrence and Liz Childers each tested negative for the BRCA gene mutation, a rare genetic mutation that increases the risk of developing breast cancer. Jordan Erb, The Indianapolis Star, "Recently diagnosed with breast cancer, twin sisters host fundraiser and raise awareness," 10 Oct. 2020 Scientists have been testing gene therapy and other ways to try to get the effect of the favorable gene mutation without having to do a transplant. Marilynn Marchione, USA TODAY, "First man cured of HIV infection known as 'the Berlin patient' now has terminal cancer," 25 Sep. 2020 Transplants are known to be an effective treatment for the blood cancer, but Huetter wanted to try to cure the HIV infection as well by using a donor with a rare gene mutation that gives natural resistance to the AIDS virus. NBC News, "Timothy Ray Brown, 1st person cured of HIV, dies of cancer," 30 Sep. 2020 Transplants are known to be an effective treatment for the blood cancer, but Huetter wanted to try to cure the HIV infection as well by using a donor with a rare gene mutation that gives natural resistance to the AIDS virus. Marilynn Marchione, USA TODAY, "Timothy Ray Brown, the first known person cured of HIV, dies of cancer at 54," 30 Sep. 2020 Hemophilia A is the more common of the two and is caused by a gene mutation that results in a defective form of blood coagulation factor VIII. Rebekah Tuchscherer, Science | AAAS, "New fusion protein treatment holds promise for people with ‘royal’ clotting disorder," 9 Sep. 2020 While conducting tests from his surgery, doctors discovered that Knowles had the BRCA2 gene mutation, which increases the risk of breast cancer in both men and women, in addition to other types of cancer. Cydney Henderson, USA TODAY, "Beyoncé's dad Mathew Knowles opens up about his breast cancer bout: 'I want to save lives'," 25 June 2020 Andrea Downing, a tech project manager and breast cancer advocate, runs the BRCA Sisterhood, a private Facebook group for women who have a gene mutation that puts them at risk for breast and ovarian cancer. Ellen Mcgirt, Fortune, "The legacy of the first openly gay presidential candidate," 2 Mar. 2020 This could be because of triple negative breast cancer’s link with BRCA gene mutations, which are often implicated in cases of people developing breast cancer before age 50. Mary Claire Lagroue, SELF, "How Is Triple Negative Breast Cancer Different from Other Diagnoses?," 31 May 2019

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'gene mutation.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of gene mutation

1904, in the meaning defined above

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The first known use of gene mutation was in 1904

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Last Updated

22 Oct 2020

Cite this Entry

“Gene mutation.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/gene%20mutation. Accessed 22 Oct. 2020.

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More Definitions for gene mutation

gene mutation

noun

Medical Definition of gene mutation

: a permanent alteration (as a point mutation or frameshift mutation) in the nucleotide sequence of a gene … there is a 50 percent chance each offspring will inherit the gene mutation and may develop the disease.— Fred Cicetti In early August the team published a study in Nature that chronicled how a single gene mutation in a laboratory strain of Escherichia coli could create a bacterium resistant to triclosan …— Gary Stix

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