gene mutation

noun
plural gene mutations

Definition of gene mutation

: a permanent alteration (as by point mutation or frameshift mutation in the nucleotide sequence of a gene Researchers have identified a gene mutation that's believed to predispose people to malignant melanoma, the deadliest and most aggressive type of skin cancer.— Health News — compare point mutation

Examples of gene mutation in a Sentence

Recent Examples on the Web

Hereditary cancer syndromes, like the ones Dr. Lynch investigated, include gene mutations that predispose some to more common cancers. New York Times, "Dr. Henry Lynch, 91, Dies; Found Hereditary Link in Cancer," 13 June 2019 The gene-editing tool has also been used to correct a disease-causing gene mutation in human embryos, preventing the mutation from passing to future generations. Fox News, "New gene-editing technology could help treat Huntington's disease, premature aging, study says," 29 Aug. 2019 Likewise, not everyone with this gene mutation gets breast cancer or ovarian cancer, according to the CDC. Mary Claire Lagroue, SELF, "How Is Triple Negative Breast Cancer Different from Other Diagnoses?," 31 May 2019 Still, the results should give encouragement to people who fear that gene mutations alone determine their destiny, said Dr. Rudy Tanzi, a genetics expert at Massachusetts General Hospital. Los Angeles Times, "Healthy living can counteract a high genetic risk of Alzheimer’s, study suggests," 15 July 2019 Still, the results should give encouragement to people who fear that gene mutations alone determine their destiny, said Dr. Rudy Tanzi, a genetics expert at Massachusetts General Hospital. Marilynn Marchione, latimes.com, "Healthy living can counteract a high genetic risk of Alzheimer’s, study suggests," 15 July 2019 The results should give encouragement to people who fear that gene mutations alone determine their destiny, said Dr. Rudy Tanzi, a genetics expert at Massachusetts General Hospital. Washington Post, "A healthy lifestyle may offset genetic risk for Alzheimer’s," 14 July 2019 The results should give encouragement to people who fear that gene mutations alone determine their destiny, said Dr. Rudy Tanzi, a genetics expert at Massachusetts General Hospital. Marilynn Marchione, The Denver Post, "A healthy lifestyle may offset genetic risk for Alzheimer’s," 14 July 2019 Recommendations about testing for BRCA and other gene mutations vary among doctors. Carolyn L. Todd, SELF, "11 Things to Know After Receiving an Ovarian Cancer Diagnosis," 14 Dec. 2018

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'gene mutation.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of gene mutation

1904, in the meaning defined above

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Last Updated

17 Sep 2019

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The first known use of gene mutation was in 1904

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More Definitions for gene mutation

gene mutation

noun

Medical Definition of gene mutation

: a permanent alteration (as a point mutation or frameshift mutation) in the nucleotide sequence of a gene … there is a 50 percent chance each offspring will inherit the gene mutation and may develop the disease.— Fred Cicetti In early August the team published a study in Nature that chronicled how a single gene mutation in a laboratory strain of Escherichia coli could create a bacterium resistant to triclosan …— Gary Stix

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