:to arouse especially mutual enmity or indifference in (someone) where there had formerly been love, affection, or friendliness :alienate
- John's excesses gradually estranged him from his mother …
- —Philip Norman
- She became estranged from her family.
:to remove from customary environment or associations
- The first words spoken were not those of one becoming estranged from this world, and already permitted to stray at times into realms foreign to the living.
- —Charlotte Brontë
her estrangement from her family