Definition of antagonism
1a
: opposition of a conflicting force, tendency, or principle
the antagonism of democracy to dictatorship
b
: actively expressed opposition or hostility
antagonism between factions personal antagonism
2
: opposition in physiological action
especially
: interaction of two or more substances such that the action of any one of them on living cells or tissues is lessened
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Merriam-Webster unabridged
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Time Traveler for antagonism
The first known use of antagonism was in 1716
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