antagonize

verb

an·​tag·​o·​nize an-ˈta-gə-ˌnīz How to pronounce antagonize (audio)
antagonized; antagonizing
Synonyms of antagonizenext

transitive verb

1
: to incur or provoke the hostility of
His criticism antagonized his friends.
2
: to act in opposition to : counteract
The drug is antagonized by methylxanthines, such as caffeine and theophylline …Scientific American Medicine

Examples of antagonize in a Sentence

He didn't mean to antagonize you. Her comments antagonized many people.
Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Investigations have linked them to vigilante groups known as militias, which often antagonized Franco. Arkansas Online, 26 Feb. 2026 After all, one of the persistent impulses of modern art has been to antagonize people of correct sensibilities, to subvert their cherished institutions. Sean Williams, Harpers Magazine, 24 Feb. 2026 Two people made extremely poor decisions to attack, antagonize and interfere with federal immigration enforcement. Voice Of The People, New York Daily News, 21 Feb. 2026 Even more important than retaining loyalists, as the Post’s recent history proves, is not deliberately antagonizing them or your own talent. John Williams, The Atlantic, 20 Feb. 2026 See All Example Sentences for antagonize

Word History

Etymology

Greek antagōnizesthai, from anti- + agōnizesthai to struggle, from agōn contest — more at agony

First Known Use

circa 1742, in the meaning defined at sense 2

Time Traveler
The first known use of antagonize was circa 1742

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Cite this Entry

“Antagonize.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/antagonize. Accessed 27 Feb. 2026.

Kids Definition

antagonize

verb
an·​tag·​o·​nize an-ˈtag-ə-ˌnīz How to pronounce antagonize (audio)
antagonized; antagonizing
: to stir up dislike or anger in

Medical Definition

antagonize

transitive verb
an·​tag·​o·​nize
variants also British antagonise
antagonized also British antagonised; antagonizing also British antagonising
: to act in antagonism to : counteract
these effects are antagonized by atropineErnest Bueding & Harry Most

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