antagonize

verb

an·​tag·​o·​nize an-ˈta-gə-ˌnīz How to pronounce antagonize (audio)
antagonized; antagonizing
Synonyms of antagonizenext

transitive verb

1
: to incur or provoke the hostility of
His criticism antagonized his friends.
2
: to act in opposition to : counteract
The drug is antagonized by methylxanthines, such as caffeine and theophylline …Scientific American Medicine

Examples of antagonize in a Sentence

He didn't mean to antagonize you. Her comments antagonized many people.
Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Vance is now tasked with the job of threading the needle; forcefully supporting and defending the administration's policies in the media while not antagonizing swing voters away from the GOP column in three years. Jesus Mesa, MSNBC Newsweek, 11 Dec. 2025 Gizelle, to her nominal credit, offers an apology for antagonizing Monique during such a sensitive time. Shamira Ibrahim, Vulture, 8 Dec. 2025 But Modi will navigate a balancing act to avoid antagonizing Washington in the midst of delicate trade negotiations. J.d. Capelouto, semafor.com, 3 Dec. 2025 Family members told deputies they were frustrated because Crump had been antagonizing others in the home, though officers said no crime had occurred. Landon Mion, FOXNews.com, 29 Nov. 2025 See All Example Sentences for antagonize

Word History

Etymology

Greek antagōnizesthai, from anti- + agōnizesthai to struggle, from agōn contest — more at agony

First Known Use

circa 1742, in the meaning defined at sense 2

Time Traveler
The first known use of antagonize was circa 1742

Browse Nearby Words

Cite this Entry

“Antagonize.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/antagonize. Accessed 13 Dec. 2025.

Kids Definition

antagonize

verb
an·​tag·​o·​nize an-ˈtag-ə-ˌnīz How to pronounce antagonize (audio)
antagonized; antagonizing
: to stir up dislike or anger in

Medical Definition

antagonize

transitive verb
an·​tag·​o·​nize
variants also British antagonise
antagonized also British antagonised; antagonizing also British antagonising
: to act in antagonism to : counteract
these effects are antagonized by atropineErnest Bueding & Harry Most

More from Merriam-Webster on antagonize

Last Updated: - Updated example sentences
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!