FIRST-LINE Synonyms: 24 Similar and Opposite Words

first-line

adjective

ˈfərst-ˈlīn

as in selected

singled out from a number or group as more to one's liking surgery is usually not considered a first-line treatment for this type of cancer

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Example Sentences

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Recent Examples of first-line That may help researchers identify which patient populations should get immunotherapy as a first-line treatment. —

Kerry Breen, CBS News, 14 Mar. 2026 The American College of Physicians recommends CBT-I as the first-line treatment for chronic insomnia. —

Allison Palmer march 4, Charlotte Observer, 4 Mar. 2026 Now, in a new paper in the journal Cell Press Blue, researchers report that if the tissue’s first-line defenses fail, then what could have been a mild infection spirals out of control. —

Veronique Greenwood, Time, 27 Feb. 2026 Metformin is the first-line medication for the treatment of type 2 diabetes. —

Tom Gavin, EverydayHealth.com, 27 Feb. 2026 See All Example Sentences for first-line

Recent Examples of Synonyms for first-line

Adjective

The gist, however, seems to be that extra-terrestrials make contact with a selected few, before promising to go public to the entire world — good luck dealing with the ramifications of that one, human race!

— Richard Edwards, Space.com, 31 Dec. 2025
The selected cohort—Diamond Batiste, Ciara Boniface, Jeremy Hsing, Alejandra López and Brittany Alexia Young—were chosen from nearly 1,000 submissions, placing them at the forefront of a new chapter in cinematic storytelling.

— Okla Jones, Essence, 23 Oct. 2025