FIRST-LINE Synonyms: 24 Similar and Opposite Words

first-line

adjective

ˈfərst-ˈlīn

as in selected

singled out from a number or group as more to one's liking surgery is usually not considered a first-line treatment for this type of cancer

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Antonyms & Near Antonyms

Example Sentences

Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.

Recent Examples of first-line Two smaller studies presented at a meeting of the American Association for Cancer Research in April found survival benefits to giving daraxonrasib as part of first-line therapy. —

Erika Edwards, NBC news, 6 May 2026 The initiative focuses on the most widely prescribed class of psychiatric medications, first-line treatments for depression and anxiety that include Zoloft, Lexapro, Paxil, and Prozac. —

Ed Silverman, STAT, 5 May 2026 Adding even one new option—such as RP1—for people whose melanoma has not responded to first-line treatments could make a big difference for patients’ prognoses. —

K. R. Callaway, Scientific American, 2 May 2026 Brock Faber had the first goal for the Wild, who were again without first-line right wing Mats Zuccarello due to an upper-body injury that occurred in Game 1 and felt his absence on their flagging power play. —

CBS News, 26 Apr. 2026 See All Example Sentences for first-line

Recent Examples of Synonyms for first-line

Adjective

These pre-selected fighter pilots and their families moved into their apartments during the summer of 1960 after residing at the Frunze Central Airfield in Moscow.

— Jeff Spry, Space.com, 27 May 2026
Viewers can earn in-game gear, weapons and other rare items by watching selected streamers who are playing Tarkov.

— Mike Stubbs, Forbes.com, 25 May 2026