: being the preferred, standard, or first choice
first-line treatment of tuberculosis
compare second-line

Examples of first-line in a Sentence

surgery is usually not considered a first-line treatment for this type of cancer
Recent Examples on the Web Modern antibiotics – streptomycin is the usual first-line treatment – can prevent complications and death if given promptly after symptoms appear. Susan Scutti, CNN, 5 July 2024 Lifestyle changes like moderate exercise and a healthy diet are often first-line suggestions. David Oliver, USA TODAY, 27 June 2024 In the other study, researchers at the University of Pennsylvania gave a combination therapy to patients with metastatic non-small cell lung cancer as a first-line treatment. Angus Chen, STAT, 20 June 2024 Metformin is a first-line medication in the treatment of type 2 diabetes and has been widely used to help control blood sugar levels since the 1960s. Jacqueline Howard, CNN, 17 June 2024 See all Example Sentences for first-line 

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'first-line.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

First Known Use

1919, in the meaning defined above

Time Traveler
The first known use of first-line was in 1919

Dictionary Entries Near first-line

Cite this Entry

“First-line.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/first-line. Accessed 27 Jul. 2024.

Medical Definition

first-line

adjective
: being the preferred, standard, or first choice
first-line treatment of advanced breast cancer
compare second-line
Last Updated: - Updated example sentences
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