second-line

adjective
sec·ond-line | \ ˈse-kᵊn(d)-ˈlīn \

Definition of second-line 

: not being the usual or preferred choice second-line drugs to treat tuberculosis — compare first-line

First Known Use of second-line

1969, in the meaning defined above

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The first known use of second-line was in 1969

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second-line

adjective
sec·ond-line | \ ˌsek-ᵊn(d)-ˌlīn \

Medical Definition of second-line 

: being or using a drug that is not the usual or preferred choice — compare first-line

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occurring twice a year or every two years

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