Synonyms of first-linenext
: being the preferred, standard, or first choice
first-line treatment of tuberculosis
compare second-line

Examples of first-line in a Sentence

surgery is usually not considered a first-line treatment for this type of cancer
Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Larkin owes his employer first-line performance for five more seasons. Fluto Shinzawa, New York Times, 5 June 2026 According to the American College of Cardiology, first-line strategies for managing high blood pressure include quitting smoking, eating a heart-healthy diet, and increasing physical activity. Fran Kritz, Verywell Health, 4 June 2026 The drug is being positioned as a first-line treatment option. Justin Zacks, CNBC, 4 June 2026 Right now, chemotherapy is still recommended as a first-line treatment for patients with advanced pancreatic cancer. Erika Edwards, NBC news, 31 May 2026 See All Example Sentences for first-line

Word History

First Known Use

1919, in the meaning defined above

Time Traveler
The first known use of first-line was in 1919

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Cite this Entry

“First-line.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/first-line. Accessed 12 Jun. 2026.

Medical Definition

first-line

adjective
: being the preferred, standard, or first choice
first-line treatment of advanced breast cancer
compare second-line
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