annoy implies a wearing on the nerves by persistent petty unpleasantness.
their constant complaining annoys us
vex implies greater provocation and stronger disturbance and usually connotes anger but sometimes perplexity or anxiety.
vexed by her son's failure to clean his room
irk stresses difficulty in enduring and the resulting weariness or impatience of spirit.
careless waste irks the boss
bother suggests interference with comfort or peace of mind.
don't bother me while I'm reading
Examples of vex in a Sentence
This problem has vexed researchers for years.
We were vexed by the delay.
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Gambling addiction is, in some sense, also especially vexing to treat.—Jasper Craven, Harpers Magazine, 27 Jan. 2026 Trump proved to be a vexing ideological lodestar—aggressively anti-intellectual in his attitudes and consistently inconsistent in his views.—Jason Zengerle, New Yorker, 24 Jan. 2026 Other therapists said the technology is also vexing their patients.—Annie Nova, CNBC, 24 Jan. 2026 Living inside a creative mind responsible for a work of art that never existed is a vexing proposition.—David John Chávez, Mercury News, 23 Jan. 2026 See All Example Sentences for vex
Word History
Etymology
Middle English, from Anglo-French vexer, from Latin vexare to agitate, harry; probably akin to Latin vehere to convey — more at way