annoy implies a wearing on the nerves by persistent petty unpleasantness.
their constant complaining annoys us
vex implies greater provocation and stronger disturbance and usually connotes anger but sometimes perplexity or anxiety.
vexed by her son's failure to clean his room
irk stresses difficulty in enduring and the resulting weariness or impatience of spirit.
careless waste irks the boss
bother suggests interference with comfort or peace of mind.
don't bother me while I'm reading
Examples of vex in a Sentence
This problem has vexed researchers for years.
We were vexed by the delay.
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Anderson argues this, beautifully and preemptively, in her piece on 2019’s vexing Ad Astra.—Literary Hub, 3 Mar. 2026 Their intimate sparring reflected vexed, unresolved tensions about science and government.—Emily Nussbaum, New Yorker, 26 Feb. 2026 In Hjorth’s recent books, these vexing others are not romantic partners but members of the narrator’s original nuclear family.—Elaine Blair, Harpers Magazine, 24 Feb. 2026 These sorts of technical challenges have vexed nuclear advocates who are fighting against a decades-long stagnation in nuclear development, triggered primarily by safety concerns.—Noah Haggerty, Los Angeles Times, 19 Feb. 2026 See All Example Sentences for vex
Word History
Etymology
Middle English, from Anglo-French vexer, from Latin vexare to agitate, harry; probably akin to Latin vehere to convey — more at way