par·​ox·​e·​tine pa-ˈräk-sə-ˌtēn How to pronounce paroxetine (audio)
: a drug C19H20FNO3 that enhances serotonin activity and is usually administered in the form of its hydrochloride to treat depression

Examples of paroxetine in a Sentence

Recent Examples on the Web For these people, antidepressants such as paroxetine, sertraline and venlafaxine are recommended as alternatives, or as an addition to psychotherapy. C. Michael White, The Conversation, 8 Nov. 2023 The lead authors are from GlaxoSmithKline, who invented paroxetine. Neuroskeptic, Discover Magazine, 6 Mar. 2011 Standard doses of fluoxetine (Prozac) and paroxetine (Paxil), two of the biggest-selling SSRI antidepressants, both had a devastating effect on the survival of mammalian nerve cells growing in a dish. Neuroskeptic, Discover Magazine, 2 May 2010 Psychedelics and trauma Why would one to two psychedelic therapy sessions be more effective than taking daily prescription medications like fluoxetine (Prozac) and paroxetine (Paxil)? Receiving a cancer diagnosis and experiencing adverse effects from treatments can be traumatic. C. Michael White, Fortune Well, 17 Apr. 2023 One of Noble's patients saw particular success with Brisdelle (paroxetine), an SSRI that’s been FDA-approved to treat hot flashes and night sweats associated with menopause. Rachel Murphy, Verywell Health, 28 Mar. 2023 Medications like fluoxetine, paroxetine, and escitalopram have shown to delay ejaculation as a side-effect of the drugs, Dr. Kaufman said. Korin Miller, Health, 23 Mar. 2023 Now a new paper claims to provide a definitive assessment of the safety and efficacy of paroxetine in adults (age 18+). Neuroskeptic, Discover Magazine, 6 Mar. 2011 In the dataset as a whole, paroxetine barely outperformed placebo. Neuroskeptic, Discover Magazine, 26 Sep. 2010 See More

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'paroxetine.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History


perhaps from International Scientific Vocabulary par- (alteration of piperidine) + ox- + methyl + -ine entry 2

First Known Use

1977, in the meaning defined above

Time Traveler
The first known use of paroxetine was in 1977

Dictionary Entries Near paroxetine

Cite this Entry

“Paroxetine.” Dictionary, Merriam-Webster, Accessed 7 Dec. 2023.

Medical Definition


par·​ox·​e·​tine par-ˈäk-sə-ˌtēn How to pronounce paroxetine (audio)
: a drug that functions as an SSRI and is usually taken orally in the form of its hydrochloride C19H20FNO3·HCl or mesylate C19H20FNO3·CH4O3S to treat depression, anxiety, panic disorder, and obsessive-compulsive disorder and to relieve symptoms (such as hot flashes) of menopause

Note: Trademarks for paroxetine include Brisdelle, Paxil, and Pexeva.

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