de·​sip·​ra·​mine də-ˈzi-prə-ˌmēn How to pronounce desipramine (audio)
: a tricyclic antidepressant C18H22N2

Examples of desipramine in a Sentence

Recent Examples on the Web The most common types of antidepressants are tricyclic antidepressants (TCAs, including desipramine and amoxapine), selective serotonin re-uptake inhibitors (SSRIs, such as Prozac, Paxil and Zoloft) and selective serotonin noradrenaline re-uptake inhibitors (SNRIs, including Cymbalta and Pristiq). Jillian Mock, Discover Magazine, 22 July 2020 Those include medications that are known antidepressants such as bupropion and desipramine. Andrea K. McDaniels,, 17 May 2018

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'desipramine.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History


desmethyl (from des- + methyl) + imipramine

First Known Use

1965, in the meaning defined above

Time Traveler
The first known use of desipramine was in 1965

Dictionary Entries Near desipramine

Cite this Entry

“Desipramine.” Dictionary, Merriam-Webster, Accessed 25 May. 2024.

Medical Definition


de·​si·​pra·​mine ˌdez-ə-ˈpram-ən How to pronounce desipramine (audio) də-ˈzip-rə-ˌmēn How to pronounce desipramine (audio)
: a tricyclic antidepressant administered in the form of its hydrochloride C18H22N2·HCl especially in the treatment of endogenous depressions (as bipolar disorder) see norpramin, pertofrane
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!