imip·​ra·​mine i-ˈmi-prə-ˌmēn How to pronounce imipramine (audio)
: a tricyclic antidepressant drug C19H24N2

Examples of imipramine in a Sentence

Recent Examples on the Web There are other drugs, like imipramine and bladder-relaxing anticholinergics, that work similarly or boost the efficacy of DDVAP, but the results are often the same. Haley Weiss, Time, 24 July 2023 The drugs were the tricyclic imipramine and the newer SSRI paroxetine. Neuroskeptic, Discover Magazine, 25 Jan. 2010 Possible treatments include blood pressure drugs like beta-blockers; anticonvulsant agents like topirimate (Topamax); and tricyclic antidepressants like imipramine (Tofranil). Jane E. Brody, New York Times, 18 Sep. 2017

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'imipramine.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History


imide + propyl + amine

First Known Use

1958, in the meaning defined above

Time Traveler
The first known use of imipramine was in 1958

Dictionary Entries Near imipramine

Cite this Entry

“Imipramine.” Dictionary, Merriam-Webster, Accessed 2 Mar. 2024.

Medical Definition


imip·​ra·​mine im-ˈip-rə-ˌmēn How to pronounce imipramine (audio)
: a tricyclic antidepressant drug administered especially in the form of its hydrochloride C19H24N2·HCl or pamoate (C19H24N2)2·C23H16O6 see tofranil

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