: a semisynthetic beta-lactam C12H17N3O4S·H2O that is derived from an antibiotic produced by a bacterium of the genus Streptomyces (S. cattleya) and is effective against gram-negative and gram-positive bacteria
Because imipenem is hydrolyzed by a dipeptidase in the kidney, it is administered with cilastatin, an inhibitor of this enzyme.
Five days before admission, the patient was evaluated by an infectious-disease specialist and readmitted to the other hospital for intravenous administration of a three-day course of imipenem-cilastatin …— Stephen I. Pelton et al., The New England Journal of Medicine, 31 Aug. 2006
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