imipenem

noun

im·​i·​pen·​em ˌi-mə-ˈpe-nəm How to pronounce imipenem (audio)
: a semisynthetic carbapenem antibiotic C12H17N3O4S·H2O that is derived from a bacterium (Streptomyces cattleya) and is effective against gram-negative and gram-positive bacteria

Word History

First Known Use

1983, in the meaning defined above

Time Traveler
The first known use of imipenem was in 1983

Dictionary Entries Near imipenem

Cite this Entry

“Imipenem.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/imipenem. Accessed 15 Jun. 2024.

Medical Definition

imipenem

noun
im·​i·​pen·​em ˌim-ə-ˈpen-əm How to pronounce imipenem (audio)
: a semisynthetic beta-lactam C12H17N3O4S·H2O that is derived from an antibiotic produced by a bacterium of the genus Streptomyces (S. cattleya) and is effective against gram-negative and gram-positive bacteria

Note: Because imipenem is hydrolyzed by a dipeptidase in the kidney, it is administered with cilastatin, an inhibitor of this enzyme.

Five days before admission, the patient was evaluated by an infectious-disease specialist and readmitted to the other hospital for intravenous administration of a three-day course of imipenem-cilastatin …Stephen I. Pelton et al., The New England Journal of Medicine
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