Medical Dictionary

cilastatin

noun ci·la·stat·in \ ˌsī-lə-ˈsta-tᵊn \
variants: also cilastatin sodium

medical Definition of cilastatin

:a drug C16H25N2O5SNa that is administered intravenously in combination with the antibiotic imipenem in order to increase its effectiveness by inhibiting enzymatic breakdown in the kidney
  • Five days before admission, the patient was evaluated by an infectious-disease specialist and readmitted to the other hospital for intravenous administration of a three-day course of imipenem–cilastatin
  • —Stephen I. Pelton et al.The New England Journal of Medicine31 Aug. 2006
  • Inclusion of cilastatin makes it possible to use imipenem against urinary tract infections.
  • Chemical & Engineering News16 Dec. 1985

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