: any of a class of broad-spectrum antibiotics (such as imipenem) resistant to hydrolysis by beta-lactamaseAnother class of antibiotics, carbapenems, is used as an antibiotic of last resort for the most persistent infections. —Nicholas Bakalar
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: any of a class of broad-spectrum beta-lactam antibiotics (such as imipenem) having a five-membered ring system similar to the penicillins but containing a carbon atom instead of a sulfur atom
It rendered the Klebsiella, which was already resistant to many antibiotics used in critical care medicine, insensitive to the only remaining group that worked reliably and safely—the carbapenems, the so-called drugs of last resort. —Maryn McKenna, Scientific American, April 2011
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