: any of a class of antidepressants (such as fluoxetine) that inhibit the inactivation of serotonin by blocking its reuptake by presynaptic neuron endings

called also selective serotonin reuptake inhibitor

Word History

First Known Use

1991, in the meaning defined above

Time Traveler
The first known use of SSRI was in 1991

Dictionary Entries Near SSRI

Cite this Entry

“SSRI.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/SSRI. Accessed 2 Jun. 2023.

Medical Definition

: any of a class of antidepressants (as fluoxetine or sertraline) that inhibit the inactivation of serotonin by blocking its reuptake by presynaptic nerve cell endings

called also selective serotonin reuptake inhibitor

compare snri
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