: any of a class of antidepressants (such as fluoxetine) that inhibit the inactivation of serotonin by blocking its reuptake by presynaptic neuron endings

called also selective serotonin reuptake inhibitor

Examples of SSRI in a Sentence

Recent Examples on the Web Many of us are also looking for ways to increase serotonin without taking a selective serotonin reuptake inhibitor, known as an SSRI. Sara Novak, Discover Magazine, 22 Dec. 2023 Additionally, these supplements, which include 5-HT, St. John’s Wart, and others, should not be taken along with an SSRI. Sara Novak, Discover Magazine, 22 Dec. 2023 If treatment without medication is unhelpful, or specific behavioral programs are not available, or the person prefers medication, then SSRI medicines, such as fluoxetine or citalopram, are often used. Dr. Keith Roach, oregonlive, 5 Sep. 2023 Your doctor may prescribe a selective serotonin reuptake inhibitor (SSRI) or another type of anti-anxiety medication. Marisa Cohen, Good Housekeeping, 26 Mar. 2023

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'SSRI.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

First Known Use

1991, in the meaning defined above

Time Traveler
The first known use of SSRI was in 1991

Dictionary Entries Near SSRI

Cite this Entry

“SSRI.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/SSRI. Accessed 25 Jun. 2024.

Medical Definition

: any of a class of antidepressants (as fluoxetine or sertraline) that inhibit the inactivation of serotonin by blocking its reuptake by presynaptic nerve cell endings

called also selective serotonin reuptake inhibitor

compare snri
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