Medical Definition of SNRI
: any of a class of drugs (as desvenlafaxine and duloxetine) that inhibit the inactivation of serotonin and norepinephrine by blocking their reuptake by presynaptic nerve cell endings and that are typically used to treat depression, anxiety, and chronic pain (such as that associated with osteoarthritis, fibromyalgia, or peripheral neuropathy)—called also selective serotonin-norepinephrine reuptake inhibitor, serotonin-norepinephrine reuptake inhibitor; compare ssri
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