hy·​al·​uron·​i·​dase | \ ˌhī(-ə)l-yu̇-ˈrä-nə-ˌdās How to pronounce hyaluronidase (audio) , -ˌdāz \

Definition of hyaluronidase

: a mucolytic enzyme that facilitates the spread of fluids through tissues by lowering the viscosity of hyaluronic acid

Examples of hyaluronidase in a Sentence

Recent Examples on the Web Fortunately, this can be treated with an injection of hyaluronidase, an enzyme that breaks down the hyaluronic acid in the filler. Sarah Jacoby, SELF, 18 May 2022 Venom from the crotaline family of snakes, such as rattlesnakes, causes damage to capillaries via metalloproteinases and hyaluronidase. Dr. Michael Daignault, USA TODAY, 26 Apr. 2022 In fact, your doctor will be able to dissolve it with an injection of an enzyme called hyaluronidase, which will work its filler-dissolving magic within about 48 hours. Kaitlin Clark, Allure, 9 Feb. 2022 One of the most common gripes doctors have with Sculptra is that there's no equivalent reversal enzyme, like hyaluronidase for HA fillers, in the event that nodules or bumps begin to form. Kaitlin Clark, Allure, 7 Feb. 2022 The side effects are rare and easily managed with antihistamines, corticosteroids, or injections of hyaluronidase. Dori Price, Good Housekeeping, 19 Mar. 2021 Always choose hyaluronic acid fillers Keep in mind that hyaluronic acid is the only type of filler that can be dissolved and reversed using hyaluronidase. Dr. Leslie Baumann, miamiherald, 11 June 2018 Yes, pretty much — hyaluronidase can deflate your fillers like a balloon. Kathleen Hou, The Cut, 9 July 2018 Because HA is not permanent, your dermatologist can inject an eraser enzyme called hyaluronidase. Brooke Shunatona, Cosmopolitan, 27 May 2015 See More

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'hyaluronidase.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

First Known Use of hyaluronidase

1940, in the meaning defined above

History and Etymology for hyaluronidase

International Scientific Vocabulary, from hyaluronic (acid) + -idase (as in glucosidase)

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Time Traveler for hyaluronidase

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The first known use of hyaluronidase was in 1940

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Dictionary Entries Near hyaluronidase

hyaluronic acid



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Last Updated

25 May 2022

Cite this Entry

“Hyaluronidase.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/hyaluronidase. Accessed 25 Jun. 2022.

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More Definitions for hyaluronidase


hy·​al·​uron·​i·​dase | \ -ˈrän-ə-ˌdās, -ˌdāz How to pronounce hyaluronidase (audio) \

Medical Definition of hyaluronidase

: a mucolytic enzyme that splits and lowers the viscosity of hyaluronic acid facilitating the spreading of fluid through tissues either advantageously (as in the absorption of drugs) or disadvantageously (as in the dissemination of infection), that occurs in many normal tissues, in malignant growths, in invasive bacteria, and in certain venoms, and that is used especially to aid in the dispersion of fluids (as local anesthetics) injected subcutaneously for therapeutic purposes

called also spreading factor

More from Merriam-Webster on hyaluronidase

Britannica.com: Encyclopedia article about hyaluronidase


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