hy·​al·​uron·​i·​dase ˌhī(-ə)l-yu̇-ˈrä-nə-ˌdās How to pronounce hyaluronidase (audio)
: a mucolytic enzyme that facilitates the spread of fluids through tissues by lowering the viscosity of hyaluronic acid

Examples of hyaluronidase in a Sentence

Recent Examples on the Web Our doctors are quick to note that Topilase is absolutely not a dupe for conventional hyaluronidase. Jolene Edgar, Harper's BAZAAR, 23 Dec. 2022 How does Topilase compare to injectable hyaluronidase? Jolene Edgar, Harper's BAZAAR, 23 Dec. 2022 Contrary to popular belief, filler doesn’t dissolve very well, even with the help of hyaluronidase, the injectable enzyme meant to reverse hyaluronic acid filler almost immediately. Hanna Lustig, Glamour, 14 Sep. 2022 That might mean adding a few more drops of filler or using a pinch of hyaluronidase to flatten out any minor puffiness. Danielle Sinay, Glamour, 7 Sep. 2022 Fortunately, this can be treated with an injection of hyaluronidase, an enzyme that breaks down the hyaluronic acid in the filler. Sarah Jacoby, SELF, 18 May 2022 Venom from the crotaline family of snakes, such as rattlesnakes, causes damage to capillaries via metalloproteinases and hyaluronidase. Dr. Michael Daignault, USA TODAY, 26 Apr. 2022 In fact, your doctor will be able to dissolve it with an injection of an enzyme called hyaluronidase, which will work its filler-dissolving magic within about 48 hours. Kaitlin Clark, Allure, 9 Feb. 2022 One of the most common gripes doctors have with Sculptra is that there's no equivalent reversal enzyme, like hyaluronidase for HA fillers, in the event that nodules or bumps begin to form. Kaitlin Clark, Allure, 7 Feb. 2022 See More

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'hyaluronidase.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History


International Scientific Vocabulary, from hyaluronic (acid) + -idase (as in glucosidase)

First Known Use

1940, in the meaning defined above

Time Traveler
The first known use of hyaluronidase was in 1940

Dictionary Entries Near hyaluronidase

Cite this Entry

“Hyaluronidase.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/hyaluronidase. Accessed 24 Sep. 2023.

Medical Definition


hy·​al·​uron·​i·​dase -ˈrän-ə-ˌdās, -ˌdāz How to pronounce hyaluronidase (audio)
: a mucolytic enzyme that splits and lowers the viscosity of hyaluronic acid facilitating the spreading of fluid through tissues either advantageously (as in the absorption of drugs) or disadvantageously (as in the dissemination of infection), that occurs in many normal tissues, in malignant growths, in invasive bacteria, and in certain venoms, and that is used especially to aid in the dispersion of fluids (as local anesthetics) injected subcutaneously for therapeutic purposes

called also spreading factor

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