phosphodiesterase

noun

phos·​pho·​di·​es·​ter·​ase ˌfäs-(ˌ)fō-dī-ˈe-stə-ˌrās How to pronounce phosphodiesterase (audio)
-ˌrāz
: a phosphatase (as from snake venom) that acts on diesters (such as some nucleotides) to hydrolyze only one of the two ester groups

Examples of phosphodiesterase in a Sentence

Recent Examples on the Web
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These undeclared ingredients are part of the phosphodiesterase (PDE-5) inhibitor drug class, which the FDA only approved for use as prescriptions under healthcare provider supervision.1234 Potential Risks and Side Effects Honey packs contain hidden tadalafil or sildenafil. Ross Phan, Verywell Health, 1 July 2025 This compound has been found to inhibit an enzyme called phosphodiesterase type 5 (PDE5), which is similar to how prescription medications like Viagra work. Amber Smith, Discover Magazine, 13 Oct. 2023 The research was funded by Cancer Research UK and the Medical Research Council, which found that phosphodiesterase type 5, or PDE5 inhibitors, can help shrink tumors in the esophagus. Joshua Hawkins, BGR, 6 Oct. 2022 To do so, the active ingredient in the drug inhibits an enzyme called phosphodiesterase 5 (PDE5) found in blood vessel walls. Sandee Lamotte, CNN, 7 Feb. 2020

Word History

First Known Use

1932, in the meaning defined above

Time Traveler
The first known use of phosphodiesterase was in 1932

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Cite this Entry

“Phosphodiesterase.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/phosphodiesterase. Accessed 10 Sep. 2025.

Medical Definition

phosphodiesterase

noun
phos·​pho·​di·​es·​ter·​ase -dī-ˈes-tə-ˌrās, -ˌrāz How to pronounce phosphodiesterase (audio)
: a phosphatase (as from snake venom) that acts on diesters (as some nucleotides) to hydrolyze only one of the two ester groups
Last Updated: - Updated example sentences
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