phosphodiesterase

noun

phos·​pho·​di·​es·​ter·​ase ˌfäs-(ˌ)fō-dī-ˈe-stə-ˌrās How to pronounce phosphodiesterase (audio)
-ˌrāz
: a phosphatase (as from snake venom) that acts on diesters (such as some nucleotides) to hydrolyze only one of the two ester groups

Example Sentences

Recent Examples on the Web The research was funded by Cancer Research UK and the Medical Research Council, which found that phosphodiesterase type 5, or PDE5 inhibitors, can help shrink tumors in the esophagus. Joshua Hawkins, BGR, 6 Oct. 2022 Tadalafil, the generic name for Cialis, is part of a family of drugs called phosphodiesterase (PDE-5) inhibitors. Chris Smith, BGR, 1 Oct. 2022 To do so, the active ingredient in the drug inhibits an enzyme called phosphodiesterase 5 (PDE5) found in blood vessel walls. Sandee Lamotte, CNN, 7 Feb. 2020

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'phosphodiesterase.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

Word History

First Known Use

1932, in the meaning defined above

Time Traveler
The first known use of phosphodiesterase was in 1932

Dictionary Entries Near phosphodiesterase

Cite this Entry

“Phosphodiesterase.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/phosphodiesterase. Accessed 30 Jan. 2023.

Medical Definition

phosphodiesterase

noun
phos·​pho·​di·​es·​ter·​ase -dī-ˈes-tə-ˌrās, -ˌrāz How to pronounce phosphodiesterase (audio)
: a phosphatase (as from snake venom) that acts on diesters (as some nucleotides) to hydrolyze only one of the two ester groups
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