COX-2 inhibitor

noun (1)
\ ˈkäks-ˈtü- How to pronounce COX-2 inhibitor (audio) \

Definition of COX-2 inhibitor

 (Entry 1 of 9)

: any of a class of drugs used to treat the pain and inflammation of arthritis by selectively blocking the variant of cyclooxygenase causing these symptoms


noun (2)
\ ˌāch-ˌī-ˈvē-ˈtü How to pronounce HIV-2 (audio) \

Definition of HIV-2 (Entry 2 of 9)

: a lentivirus (species Human immunodeficiency virus 2) that causes AIDS especially in western Africa, is closely related in structure to SIV of monkeys, and is less virulent than HIV-1


noun (3)
in·​ter·​leu·​kin-2 | \ ˌin-tər-ˈlü-kən-ˈtü How to pronounce interleukin-2 (audio) \

Definition of interleukin-2 (Entry 3 of 9)

: an interleukin produced by antigen-stimulated helper T cells in the presence of interleukin-1 that induces proliferation of immune cells (such as T cells and B cells) and is used experimentally especially in treating certain cancers


noun (4)
\ ˌtü-ˌfȯr-ˈdē How to pronounce 2,4-D (audio) \

Definition of 2,4-D (Entry 4 of 9)

: a white crystalline irritant compound C8H6Cl2O3 used especially as a weed killer


noun (5)
\ ˌtü-ˌfȯr-ˌfīv-ˈtē How to pronounce 2,4,5-T (audio) \

Definition of 2,4,5-T (Entry 5 of 9)

: an irritant crystalline compound C8H5Cl3O3 used especially formerly chiefly as an herbicide and defoliant

type 2 diabetes

noun (6)
\ ˈtīp-ˈtü- How to pronounce type 2 diabetes (audio) \

Definition of type 2 diabetes (Entry 6 of 9)

: a common form of diabetes mellitus that develops especially in adults and most often in obese individuals and that is characterized by hyperglycemia resulting from impaired insulin utilization coupled with the body's inability to compensate with increased insulin production

called also non-insulin-dependent diabetes, non-insulin-dependent diabetes mellitus, type 2 diabetes mellitus

\ ˈvē-ˈtü How to pronounce V-2 (audio) \

Definition of V-2 (Entry 7 of 9)

: a rocket-propelled bomb of German invention

2 ²/₃′ pitch

noun (8)

Definition of 2 ²/₃′ pitch (Entry 8 of 9)

: one octave and a fifth above the normal pitch of a given key on the organ an organ stop of 2 2/3′ pitch
\ ˈtü-ˌpȯint-ˈō How to pronounce 2.0 (audio) \

Definition of 2.0 (Entry 9 of 9)

used postpositively to describe a new and improved version or example of something or someone… data previously collected by the planet-hunting telescope are turning up a trove of strange and wonderful worlds, bringing researchers closer, they hope, to finding “Earth 2.0.”— Amina Khan, Los Angeles Times, 27 Feb. 2014Everyone agrees that the new [Doug] Bruce is no longer the arrogant overachiever he used to be. He's Doug 2.0, shaggier and nicer …— Ty Burr, Boston Globe, 24 Mar. 2006

Examples of COX-2 inhibitor in a Sentence

Recent Examples on the Web: Noun In Paris, David Klatzmann, an immunologist at Sorbonne University, is experimenting with treating autoimmune disorders with low levels of interleukin-2 (IL-2), an immune-signaling molecule first used to treat cancer in the mid-1980s. Karen Weintraub, Scientific American, "Could Immunotherapy Treat Diseases Besides Cancer?," 30 Sep. 2019 Synthorx has developed a partly artificial version of interleukin-2, a natural compound with anti-cancer activity. San Diego Union-Tribune, "Biotech Notebook: Treasure from cellular trash; science gets artsy at Symphony at Salk," 26 July 2019 Researchers studying the immune system discovered the molecules interferon and interleukin-2; each was initially hailed as a promising treatment based on their dramatic effects in shrinking tumors in rodents. Jerome Groopman, The New York Review of Books, "The Body Strikes Back," 21 Mar. 2019 Eventually, the company produced a partly synthetic DNA code that modified interleukin-2 and similar molecules to eliminate the immune-suppressing effects, Shawver said. Bradley J. Fikes,, "La Jolla biotech raises $63 million to make cancer drugs from artificial DNA," 30 Apr. 2018 One of these proteins, called interleukin-2, has been studied for decades as an immune-stimulating cancer therapy. Bradley J. Fikes,, "La Jolla biotech raises $63 million to make cancer drugs from artificial DNA," 30 Apr. 2018 She was also given interleukin-2, a substance that stimulates killer T-cells. Denise Grady, New York Times, "1 Patient, 7 Tumors and 100 Billion Cells Equal 1 Striking Recovery," 7 Dec. 2016 Recent Examples on the Web: Noun The state has more fatal overdoses, a higher infant mortality rate and a higher rate of adults with type 2 diabetes than the national average. Jessie Balmert, USA TODAY, "How sex ed debate has kept Ohio from setting standards on teaching health," 18 Dec. 2019 As part of that strategic shift, the French drug giant will pull back from an ambitious venture to use digital tools to help patients manage their type 2 diabetes, the company told investors. Rebecca Robbins, STAT, "What Sanofi’s withdrawal from diabetes tech tells us about digital health," 11 Dec. 2019 Prediabetes is a serious health condition in which a person’s levels of blood glucose (also known as blood sugar) are consistently elevated, but not to the point of having type 2 diabetes. Carolyn L. Todd, SELF, "Viola Davis on Being Diagnosed With Prediabetes: ‘I Was Shocked’," 1 May 2019 In fact, research suggests that diet soda may be associated with conditions including type 2 diabetes, heart disease and Alzheimer’s, not to mention weight gain. Jamie Ducharme, Time, "This 104-Year-Old Woman Drinks a Diet Coke Every Day," 5 Jan. 2018 Several studies have linked fast eating with weight gain and bigger weight fluctuations and this habit is also associated with a higher risk of type 2 diabetes. Samantha Cassetty, NBC News, "10 tips to avoid those letting healthy habits slip during the holidays," 11 Dec. 2019 Eating too much sugar is making us obese, and giving us hypertension, type 2 diabetes, and heart disease., "restrictions on vaping products," 29 Sep. 2019 The last decade was marked by the passage of several municipal soda tax initiatives, almost all of them based on the assumption that sweetened beverages have contributed to the rise of rates of obesity and type 2 diabetes. Chase Purdy, Quartz, "A US appeals court just hollowed out the meaning of ‘diet’ foods," 31 Dec. 2019 This time as a treatment for obesity and type 2 diabetes. Kimberly Wilson, Essence, "Considering Keto In The New Year? Here’s What You Need To Know," 31 Dec. 2019

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'COX-2 inhibitor.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of COX-2 inhibitor

Noun (1)

1994, in the meaning defined above

Noun (2)

1986, in the meaning defined above

Noun (3)

1979, in the meaning defined above

Noun (4)

circa 1945, in the meaning defined above

Noun (5)

1946, in the meaning defined above

Noun (6)

1982, in the meaning defined above

Noun (7)

1944, in the meaning defined above


1983, in the meaning defined above

History and Etymology for COX-2 inhibitor

Noun (4)


Noun (5)


Noun (7)

German, abbreviation for Vergeltungswaffe 2, literally, reprisal weapon 2

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Time Traveler for COX-2 inhibitor

Time Traveler

The first known use of COX-2 inhibitor was in 1944

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Statistics for COX-2 inhibitor

Cite this Entry

“COX-2 inhibitor.” Dictionary, Merriam-Webster, Accessed 19 Feb. 2020.

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More Definitions for COX-2 inhibitor

COX-2 inhibitor

variants: also COX-2 blocker

Medical Definition of COX-2 inhibitor

: any of a class of drugs (as celecoxib) that are NSAIDs which selectively block the isoform COX-2 but not the isoform COX-1 of cyclooxygenase and are used chiefly to relieve the pain and inflammation of arthritis while minimizing gastrointestinal side effects COX-2 inhibitors, as their name implies, were designed to block just the inflammatory functions of the COX-2 enzyme, leaving the stomach-protecting functions of the COX-1 form intact.— Alice Park, Time, 28 Feb. 2005

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