Definition of TIRE

to diminish the physical strength of <I don't want our walk to tire you too much>
Antonyms beef (up), fortify, strengthen
to make weary and restless by being dull or monotonous <this long dry lecture will tire the audience if you don't insert some jokes into it>
Synonyms jade, tire, weary
to use up all the physical energy of <this pentathlon will tire all but the hardiest athletes>

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