Synonyms and Antonyms of vicissitude
a negative event or circumstance that is common to a particular setting or situation and is usually beyond one's control
- The vicissitudes of medical school proved too much for the anxious student.
adversity, affliction, asperity, misadventure, mischance, misfortune, mishap, privation, tragedy, tribulation, trouble, woe
cross, crucible, fire, gauntlet (also gantlet), ordeal, trial
acid test, litmus test
challenge, complication, difficulty, grief, grievance, hardship, rigor
annoyance, discomfort, inconvenience, nuisance