2
: an abnormal change in structure of an organ or part due to injury or disease
especially
: one that is circumscribed (see circumscribe sense 1) and well-defined
Examples of lesion in a Sentence
Recent Examples on the Web
The lesions can cause severe suffering and, depending on the location, can cause pain when using the bathroom or eating.
—
Natalie Neysa Alund, USA Today, 3 June 2026
In a large clinical trial published in the New England Journal of Medicine, the Shield test made by Guardant Health detected 83 percent case of colon cancer, but only 13 percent of advanced precancerous lesions.
—The Washington Post, San Diego Union-Tribune, 2 June 2026
For bloodstream infections, patients can experience dangerously low blood pressure and blistering skin lesions.
—Vanessa Etienne, PEOPLE, 1 June 2026
Mpox spreads through close, direct contact with an infected person’s skin lesions, scabs, or body fluids.
—Rick Sobey, Boston Herald, 28 May 2026
See All Example Sentences for lesion
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Natalie Neysa Alund, USA Today, 3 June 2026
In a large clinical trial published in the New England Journal of Medicine, the Shield test made by Guardant Health detected 83 percent case of colon cancer, but only 13 percent of advanced precancerous lesions.
—The Washington Post, San Diego Union-Tribune, 2 June 2026
For bloodstream infections, patients can experience dangerously low blood pressure and blistering skin lesions.
—Vanessa Etienne, PEOPLE, 1 June 2026
Mpox spreads through close, direct contact with an infected person’s skin lesions, scabs, or body fluids.
—Rick Sobey, Boston Herald, 28 May 2026
See All Example Sentences for lesion
Cite this Entry
“Lesion.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/lesion. Accessed 14 Jun. 2026.
Copy CitationKids Definition
lesion
noun
le·sion
ˈlē-zhən 
: a change in the structure of a bodily organ or part due to injury or disease
especially
: an injured or diseased spot or area clearly marked off from healthy tissue around it
Medical Definition
Legal Definition
lesion
noun
le·sion
ˈlē-zhən
in the civil law of Louisiana
: loss from failure to receive a threshold amount or value (as one-half market value) for immovable property conveyed or transferred by a commutative contract (as a sale or exchange)
called also lesion beyond moiety
compare unjust enrichmentEtymology
Anglo-French, damage, injury, from Latin laesio, from laedere to injure
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