2
: an abnormal change in structure of an organ or part due to injury or disease
especially
: one that is circumscribed (see circumscribe sense 1) and well-defined
Examples of lesion in a Sentence
Recent Examples on the Web
In rare cases, mpox can lead to eye infections, severe rash, painful skin lesions and neurological problems.
—
Melissa Rudy, FOXNews.com, 16 Mar. 2026
Last summer, Brossoit and doctors, after examining his right hip, found the root cause of the knee pain — a cam lesion on the head of his femur that was causing issues with cartilage inside the joint.
—Curtis Pashelka, Mercury News, 15 Mar. 2026
In the fall of 2023, doctors removed a benign lesion from Woodland’s brain in a craniotomy.
—Gabby Herzig, New York Times, 10 Mar. 2026
Disease While dogwood anthracnose (Discula destructiva) doesn't affect the number of blooms directly, the fungus, which starts out as leaf spots, can spread and cause dark lesions (cankers) that can kill the branches and, eventually, kill the tree.
—Mary Marlowe Leverette, Southern Living, 5 Mar. 2026
See All Example Sentences for lesion
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Melissa Rudy, FOXNews.com, 16 Mar. 2026
Last summer, Brossoit and doctors, after examining his right hip, found the root cause of the knee pain — a cam lesion on the head of his femur that was causing issues with cartilage inside the joint.
—Curtis Pashelka, Mercury News, 15 Mar. 2026
In the fall of 2023, doctors removed a benign lesion from Woodland’s brain in a craniotomy.
—Gabby Herzig, New York Times, 10 Mar. 2026
Disease While dogwood anthracnose (Discula destructiva) doesn't affect the number of blooms directly, the fungus, which starts out as leaf spots, can spread and cause dark lesions (cankers) that can kill the branches and, eventually, kill the tree.
—Mary Marlowe Leverette, Southern Living, 5 Mar. 2026
See All Example Sentences for lesion
Cite this Entry
“Lesion.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/lesion. Accessed 22 Mar. 2026.
Copy CitationKids Definition
lesion
noun
le·sion
ˈlē-zhən 
: a change in the structure of a bodily organ or part due to injury or disease
especially
: an injured or diseased spot or area clearly marked off from healthy tissue around it
Medical Definition
Legal Definition
lesion
noun
le·sion
ˈlē-zhən
in the civil law of Louisiana
: loss from failure to receive a threshold amount or value (as one-half market value) for immovable property conveyed or transferred by a commutative contract (as a sale or exchange)
called also lesion beyond moiety
compare unjust enrichmentEtymology
Anglo-French, damage, injury, from Latin laesio, from laedere to injure
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