an·ti·de·pres·sant
ˌan-tē-di-ˈpre-sᵊnt 
ˌan-ˌtī-
ˌan-ˌtī-
: used or tending to relieve or prevent depression
antidepressant drugs
: an antidepressant drug see ssri, tricyclic antidepressant
Examples of antidepressant in a Sentence
Recent Examples on the Web
Erica Sloan, SELF, 25 July 2025
Certain studies have found a slightly elevated risk of miscarriage associated with antidepressant use in pregnancy.
—Josh Feldman, NBC news, 22 July 2025
Laura Trujillo, USA Today, 23 July 2025
When asked to identify their drug of choice for self-medicating eating disorder symptoms, the most popular drug among respondents was cannabis, but when normalized by number of users, fluoxetine, an antidepressant, ranked highest.
—Dario Sabaghi, Forbes.com, 23 July 2025
See All Example Sentences for antidepressant
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Adjective
These omegas are anti-inflammatory powerhouses, known to reduce body and brain inflammation through a bunch of different pathways that researchers suspect may have antidepressant effects.
—Erica Sloan, SELF, 25 July 2025
Certain studies have found a slightly elevated risk of miscarriage associated with antidepressant use in pregnancy.
—Josh Feldman, NBC news, 22 July 2025
Noun
The antidepressants treat their symptoms, rather than the cause, and could make things worse.
—Laura Trujillo, USA Today, 23 July 2025
When asked to identify their drug of choice for self-medicating eating disorder symptoms, the most popular drug among respondents was cannabis, but when normalized by number of users, fluoxetine, an antidepressant, ranked highest.
—Dario Sabaghi, Forbes.com, 23 July 2025
See All Example Sentences for antidepressant
Cite this Entry
“Antidepressant.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/antidepressant. Accessed 20 Aug. 2025.
Copy CitationMedical Definition
antidepressant
1 of 2 adjective
an·ti·de·pres·sant
ˌant-i-di-ˈpres-ᵊnt, ˌan-ˌtī-
variants
also antidepressive
: used or tending to relieve or prevent psychological depression : relating to, being, or utilizing an antidepressant
an antidepressant drug
antidepressant treatment
antidepressant
2 of 2 noun
variants
also antidepressive
: a drug used to treat psychological depression : an antidepressant drug
The dual-action antidepressant venlafaxine appears to demonstrate superior efficacy and higher rates of remission in severe depression as compared with either SSRIs such as fluoxetine or tricyclic antidepressants.—John Mann, The New England Journal of Medicine
John Mann, The New England Journal of Medicinecalled also energizer, psychic energizer, psychostimulant
see tricyclic antidepressantLove words? Need even more definitions?
Merriam-Webster unabridged
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