an·ti·de·pres·sant
ˌan-tē-di-ˈpre-sᵊnt 
ˌan-ˌtī-
ˌan-ˌtī-
: used or tending to relieve or prevent depression
antidepressant drugs
: an antidepressant drug see ssri, tricyclic antidepressant
Examples of antidepressant in a Sentence
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Annika Kim Constantino,jacob Pramuk, CNBC, 21 Nov. 2025
Saffron was identified as most effective, showing a moderate to large antidepressant effect.
—Angelica Stabile, FOXNews.com, 19 Nov. 2025
Angelica Stabile, FOXNews.com, 19 Nov. 2025
In July 2021, Selena filmed herself taking an overdose of antidepressants and posted it on Snapchat.
—Charlotte Alter, Time, 19 Nov. 2025
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Adjective
That included insulins, the antidepressant pill Prozac and the earliest polio vaccine.
—Annika Kim Constantino,jacob Pramuk, CNBC, 21 Nov. 2025
Saffron was identified as most effective, showing a moderate to large antidepressant effect.
—Angelica Stabile, FOXNews.com, 19 Nov. 2025
Noun
One specific spice could function as a natural antidepressant, an expert says.
—Angelica Stabile, FOXNews.com, 19 Nov. 2025
In July 2021, Selena filmed herself taking an overdose of antidepressants and posted it on Snapchat.
—Charlotte Alter, Time, 19 Nov. 2025
See All Example Sentences for antidepressant
Cite this Entry
“Antidepressant.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/antidepressant. Accessed 29 Nov. 2025.
Copy CitationMedical Definition
antidepressant
1 of 2 adjective
an·ti·de·pres·sant
ˌant-i-di-ˈpres-ᵊnt, ˌan-ˌtī-
variants
also antidepressive
: used or tending to relieve or prevent psychological depression : relating to, being, or utilizing an antidepressant
an antidepressant drug
antidepressant treatment
antidepressant
2 of 2 noun
variants
also antidepressive
: a drug used to treat psychological depression : an antidepressant drug
The dual-action antidepressant venlafaxine appears to demonstrate superior efficacy and higher rates of remission in severe depression as compared with either SSRIs such as fluoxetine or tricyclic antidepressants.—John Mann, The New England Journal of Medicine
John Mann, The New England Journal of Medicinecalled also energizer, psychic energizer, psychostimulant
see tricyclic antidepressantLove words? Need even more definitions?
Merriam-Webster unabridged
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