antidepressant

1 of 2

adjective

an·​ti·​de·​pres·​sant ˌan-tē-di-ˈpre-sᵊnt  ˌan-ˌtī- 

: used or tending to relieve or prevent depression

antidepressant drugs

antidepressant

2 of 2

noun

: an antidepressant drug see ssri, tricyclic antidepressant

Examples of antidepressant in a Sentence

Recent Examples on the Web

Adjective

Before the pandemic, only 1% to 2% of antidepressant medications were prescribed via telehealth. — Andrew McLean, The Conversation, 10 Sep. 2026

Major studies show that meditation can alleviate anxiety and depression—at least about as well as the antidepressant Lexapro can, but without the cost and with fewer side effects. — Olga Khazan, The Atlantic, 4 Sep. 2026

Noun

Last December, Gerber posted a video to Instagram detailing his use of prescription medication, including antidepressants and Xanax for panic attacks. — Oscar Holland, CNN Money, 21 Sep. 2026

Usually, antidepressants will increase the availability of serotonin. — Amber Raiken, Verywell Health, 18 Sep. 2026

Word History

First Known Use

Adjective

1961, in the meaning defined above

Noun

1962, in the meaning defined above

Phrases Containing antidepressant

• tricyclic antidepressant

Rhymes for antidepressant

• preadolescent
• acquiescent
• adolescent
• arborescent
• coalescent
• convalescent
• deliquescent
• effervescent
• evanescent
• incandescent
• iridescent
• luminescent

Medical Definition

antidepressant

1 of 2 adjective

an·​ti·​de·​pres·​sant ˌant-i-di-ˈpres-ᵊnt, ˌan-ˌtī- 

variants also antidepressive

-ˈpres-iv 

: used or tending to relieve or prevent psychological depression : relating to, being, or utilizing an antidepressant

an antidepressant drug

antidepressant treatment

antidepressant

2 of 2 noun

variants also antidepressive

: a drug used to treat psychological depression : an antidepressant drug

The dual-action antidepressant venlafaxine appears to demonstrate superior efficacy and higher rates of remission in severe depression as compared with either SSRIs such as fluoxetine or tricyclic antidepressants.

—John Mann, The New England Journal of Medicine

called also energizer, psychic energizer, psychostimulant

see tricyclic antidepressant