an·ti·de·pres·sant
ˌan-tē-di-ˈpre-sᵊnt 
ˌan-ˌtī-
ˌan-ˌtī-
: used or tending to relieve or prevent depression
antidepressant drugs
: an antidepressant drug see ssri, tricyclic antidepressant
Examples of antidepressant in a Sentence
Recent Examples on the Web
Nick Mordowanec, MSNBC Newsweek, 22 May 2025
Serotonin Syndrome Methylene blue interacts with several antidepressant drugs, and the combination can potentially lead to serotonin syndrome, a serious drug reaction caused by high levels of serotonin in the body.
—Tom Gavin, EverydayHealth.com, 12 May 2025
Alyce Collins, MSNBC Newsweek, 5 July 2025
He was prescribed 75 mg of Trazodone, an antidepressant often used for sleep disorders even though the FDA has not approved it for that use, and 4 mg of Risperidone, an antipsychotic, his lawsuit alleges.
—Graham Rayman, New York Daily News, 24 June 2025
See All Example Sentences for antidepressant
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Adjective
Meanwhile, antidepressant prescription rates in teens increased by 1,400 percent between 1987 and 2014.
Between 1999 and 2018, the pharmaceutical industry purportedly spent $4.7 billion on lobbying expenditures at the federal level—more than any other industry.
—Nick Mordowanec, MSNBC Newsweek, 22 May 2025
Serotonin Syndrome Methylene blue interacts with several antidepressant drugs, and the combination can potentially lead to serotonin syndrome, a serious drug reaction caused by high levels of serotonin in the body.
—Tom Gavin, EverydayHealth.com, 12 May 2025
Noun
Most commonly with antidepressants, psychotherapy, or a combination of the two.
—Alyce Collins, MSNBC Newsweek, 5 July 2025
He was prescribed 75 mg of Trazodone, an antidepressant often used for sleep disorders even though the FDA has not approved it for that use, and 4 mg of Risperidone, an antipsychotic, his lawsuit alleges.
—Graham Rayman, New York Daily News, 24 June 2025
See All Example Sentences for antidepressant
Cite this Entry
“Antidepressant.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/antidepressant. Accessed 14 Jul. 2025.
Copy CitationMedical Definition
antidepressant
1 of 2 adjective
an·ti·de·pres·sant
ˌant-i-di-ˈpres-ᵊnt, ˌan-ˌtī-
variants
also antidepressive
: used or tending to relieve or prevent psychological depression : relating to, being, or utilizing an antidepressant
an antidepressant drug
antidepressant treatment
antidepressant
2 of 2 noun
variants
also antidepressive
: a drug used to treat psychological depression : an antidepressant drug
The dual-action antidepressant venlafaxine appears to demonstrate superior efficacy and higher rates of remission in severe depression as compared with either SSRIs such as fluoxetine or tricyclic antidepressants.—John Mann, The New England Journal of Medicine
John Mann, The New England Journal of Medicinecalled also energizer, psychic energizer, psychostimulant
see tricyclic antidepressantLove words? Need even more definitions?
Merriam-Webster unabridged
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