an·ti·de·pres·sant
ˌan-tē-di-ˈpre-sᵊnt 
ˌan-ˌtī-
ˌan-ˌtī-
: used or tending to relieve or prevent depression
antidepressant drugs
: an antidepressant drug see ssri, tricyclic antidepressant
Examples of antidepressant in a Sentence
Recent Examples on the Web
Literary Hub, 10 Feb. 2026
Investigators found medications, including an antidepressant and antihistamine drugs, in Monique’s system at the time of her death.
—Sarah Rumpf-Whitten , Adam Sabes, FOXNews.com, 3 Feb. 2026
Jocelyn Solis-Moreira, Flow Space, 13 Feb. 2026
The same is true for Pristiq, an antidepressant.
—Nicholas Florko, The Atlantic, 6 Feb. 2026
See All Example Sentences for antidepressant
Examples are automatically compiled from online sources to
show current usage.
Read More
Opinions expressed in the examples do not represent those of Merriam-Webster or its editors.
Send us feedback.
Adjective
But there was never an offer of pain medication; only antidepressant after antidepressant, despite no diagnosis of depression.
—Literary Hub, 10 Feb. 2026
Investigators found medications, including an antidepressant and antihistamine drugs, in Monique’s system at the time of her death.
—Sarah Rumpf-Whitten , Adam Sabes, FOXNews.com, 3 Feb. 2026
Noun
While many of the common treatments for menopause can help with mood changes, your provider may also recommend other types of treatment such as antidepressants.
—Jocelyn Solis-Moreira, Flow Space, 13 Feb. 2026
The same is true for Pristiq, an antidepressant.
—Nicholas Florko, The Atlantic, 6 Feb. 2026
See All Example Sentences for antidepressant
Cite this Entry
“Antidepressant.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/antidepressant. Accessed 18 Feb. 2026.
Copy CitationMedical Definition
antidepressant
1 of 2 adjective
an·ti·de·pres·sant
ˌant-i-di-ˈpres-ᵊnt, ˌan-ˌtī-
variants
also antidepressive
: used or tending to relieve or prevent psychological depression : relating to, being, or utilizing an antidepressant
an antidepressant drug
antidepressant treatment
antidepressant
2 of 2 noun
variants
also antidepressive
: a drug used to treat psychological depression : an antidepressant drug
The dual-action antidepressant venlafaxine appears to demonstrate superior efficacy and higher rates of remission in severe depression as compared with either SSRIs such as fluoxetine or tricyclic antidepressants.—John Mann, The New England Journal of Medicine
John Mann, The New England Journal of Medicinecalled also energizer, psychic energizer, psychostimulant
see tricyclic antidepressantLove words? Need even more definitions?
Merriam-Webster unabridged
