an·ti·de·pres·sant
ˌan-tē-di-ˈpre-sᵊnt 
ˌan-ˌtī-
ˌan-ˌtī-
: used or tending to relieve or prevent depression
antidepressant drugs
: an antidepressant drug see ssri, tricyclic antidepressant
Examples of antidepressant in a Sentence
Recent Examples on the Web
Joan MacDonald, Forbes.com, 21 Apr. 2025
Inflammation and metabolic dysfunction underly anhedonia-like behavior in antidepressant resistant male rats
Before joining Discover Magazine, Paul Smaglik spent over 20 years as a science journalist, specializing in U.S. life science policy and global scientific career issues.
—Paul Smaglik, Discover Magazine, 2 Apr. 2025
Khloe Quill, FOXNews.com, 23 Apr. 2025
This marks a notable increase over more conventional antidepressant therapy treatments, whose remission rates hover around 45 percent.
—John Semley, Rolling Stone, 19 Apr. 2025
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Adjective
In the story an antidepressant pharmaceutical company accidentally creates a love virus.
—Joan MacDonald, Forbes.com, 21 Apr. 2025
Inflammation and metabolic dysfunction underly anhedonia-like behavior in antidepressant resistant male rats
Before joining Discover Magazine, Paul Smaglik spent over 20 years as a science journalist, specializing in U.S. life science policy and global scientific career issues.
—Paul Smaglik, Discover Magazine, 2 Apr. 2025
Noun
It has previously been proposed that probiotics — like antidepressants — may reduce both positive and negative emotions, according to the report.
—Khloe Quill, FOXNews.com, 23 Apr. 2025
This marks a notable increase over more conventional antidepressant therapy treatments, whose remission rates hover around 45 percent.
—John Semley, Rolling Stone, 19 Apr. 2025
See All Example Sentences for antidepressant
Cite this Entry
“Antidepressant.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/antidepressant. Accessed 2 May. 2025.
Copy CitationMedical Definition
antidepressant
1 of 2 adjective
an·ti·de·pres·sant
ˌant-i-di-ˈpres-ᵊnt, ˌan-ˌtī-
variants
also antidepressive
: used or tending to relieve or prevent psychological depression : relating to, being, or utilizing an antidepressant
an antidepressant drug
antidepressant treatment
antidepressant
2 of 2 noun
variants
also antidepressive
: a drug used to treat psychological depression : an antidepressant drug
The dual-action antidepressant venlafaxine appears to demonstrate superior efficacy and higher rates of remission in severe depression as compared with either SSRIs such as fluoxetine or tricyclic antidepressants.—John Mann, The New England Journal of Medicine
John Mann, The New England Journal of Medicinecalled also energizer, psychic energizer, psychostimulant
see tricyclic antidepressantLove words? Need even more definitions?
Merriam-Webster unabridged
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