an·​ti·​de·​pres·​sant | \ ˌan-tē-di-ˈpre-sᵊnt How to pronounce antidepressant (audio) , ˌan-ˌtī- How to pronounce antidepressant (audio) \

Definition of antidepressant

 (Entry 1 of 2)

: used or tending to relieve or prevent depression antidepressant drugs



Definition of antidepressant (Entry 2 of 2)

Examples of antidepressant in a Sentence

Recent Examples on the Web: Adjective Neither the antidepressant fluvoxamine, often used to treat obsessive-compulsive disorder, nor the gout drug colchicine, was shown to provide benefit to COVID-19 patients. Adrianna Rodriguez, USA TODAY, 16 July 2022 Closer inspection showed that the pills that were in the laxative bottle were actually antidepressant pills, officials said. Jodicee Arianna, The Arizona Republic, 30 June 2022 Since then, ketamine’s antidepressant potential has captivated researchers, pharmaceutical companies and patients alike. Raleigh Mcelvery, Smithsonian Magazine, 24 May 2022 Adults aged 18-39 are suffering the most, and females are twice as likely to experience anxiety as men and twice as likely to be prescribed anti-anxiety or antidepressant medication. Marija Butkovic, Forbes, 11 July 2022 One 13-year-old rising eighth grader in Colorado currently takes the antidepressant Paxil and the stimulant Adderall. New York Times, 9 July 2022 Tygart’s agency chose not to pursue any penalty after determining an antidepressant Martinez was taking caused the elevated level. oregonlive, 3 July 2022 More than 70 years after the initial observations, patients diagnosed with PTSD today still have few treatment options; most likely they will be prescribed a combination of therapy and antidepressant drugs. Emma Yasinski, Smithsonian Magazine, 3 May 2022 Nonstimulant medications used to treat ADHD in adults include atomoxetine, which increases the brain neurotransmitter norepinephrine, and bupropion, an antidepressant drug sometimes used to treat ADHD that increases both dopamine and norepinephrine. Laura E. Knouse, The Conversation, 9 May 2022 Recent Examples on the Web: Noun Late last year, Merryman had sharply reduced his dosage of Cymbalta, an antidepressant, which could have caused his psychotic break, Koshes reported. Paul Duggan, Washington Post, 1 July 2022 In another study, scientists found that even at low levels in the environment, an antidepressant called fluoxetine resulted in starlings feeding less often than usual during their foraging routines that take place at sunrise and sunset. Anuradha Varanasi, Forbes, 24 June 2022 Gil was taking the antidepressant trazodone, medical records show. Kelly Davis, San Diego Union-Tribune, 4 Apr. 2022 Fluvoxamine, an antidepressant pill that is approved in the U.S. for obsessive-compulsive disorder, can tame inflammatory responses, which typically arise in severe COVID-19. Esther Landhuis, Scientific American, 21 Jan. 2022 Her mix of psychotropic pills shifted, expanded: antipsychotics, mood stabilizers, an antidepressant, a benzodiazepine for anxiety, a stimulant for attention deficit. New York Times, 17 May 2022 Long gone are the days when health plans and PBMs had to worry about the launch of a new cholesterol pill or prescription antidepressant that would cost $4 each and be taken by millions of Americans. Bruce Japsen, Forbes, 3 May 2022 Topline The Food and Drug Administration on Monday declined to authorize a cheap and widely available antidepressant as a treatment for Covid-19, finding that a study indicating the drug was effective against the disease was severely limited. Zachary Snowdon Smith, Forbes, 16 May 2022 Wellbutrin is a brand name of bupropion, a prescription antidepressant approved by the Food and Drug Administration in 1985 that is sometimes used to treat attention-deficit/hyperactivity disorder, or ADHD. Washington Post, 4 May 2022 See More

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'antidepressant.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

First Known Use of antidepressant


1961, in the meaning defined above


1962, in the meaning defined above

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The first known use of antidepressant was in 1961

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Last Updated

8 Aug 2022

Cite this Entry

“Antidepressant.” Dictionary, Merriam-Webster, Accessed 9 Aug. 2022.

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More Definitions for antidepressant


an·​ti·​de·​pres·​sant | \ ˌant-i-di-ˈpres-ᵊnt, ˌan-ˌtī- How to pronounce antidepressant (audio) \
variants: also antidepressive \ -​ˈpres-​iv How to pronounce antidepressant (audio) \

Medical Definition of antidepressant

 (Entry 1 of 2)

: used or tending to relieve or prevent psychological depression : relating to, being, or utilizing an antidepressant an antidepressant drug antidepressant treatment


variants: also antidepressive

Medical Definition of antidepressant (Entry 2 of 2)

: a drug used to treat psychological depression : an antidepressant drug The dual-action antidepressant venlafaxine appears to demonstrate superior efficacy and higher rates of remission in severe depression as compared with either SSRIs such as fluoxetine or tricyclic antidepressants.— John Mann, The New England Journal of Medicine

called also energizer, psychic energizer, psychostimulant

— see tricyclic antidepressant


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