an·ti·de·pres·sant
ˌan-tē-di-ˈpre-sᵊnt 
ˌan-ˌtī-
ˌan-ˌtī-
: used or tending to relieve or prevent depression
antidepressant drugs
: an antidepressant drug see ssri, tricyclic antidepressant
Examples of antidepressant in a Sentence
Recent Examples on the Web
Michelle Lee, PEOPLE, 31 Dec. 2025
In this study, slow tapering was a gradual reduction in antidepressant dosage over the course of four weeks or more.
—Emily Kay Votruba, EverydayHealth.com, 11 Dec. 2025
New Atlas, 4 Jan. 2026
Mehta also noted that the findings are not a substitute for traditional antidepressants.
—Deirdre Bardolf, FOXNews.com, 3 Jan. 2026
See All Example Sentences for antidepressant
Examples are automatically compiled from online sources to
show current usage.
Read More
Opinions expressed in the examples do not represent those of Merriam-Webster or its editors.
Send us feedback.
Adjective
Kaia and Presley, who recently opened up about being on antidepressant medications for his mental health, weren't present in the family photo shared to Crawford's Instagram.
—Michelle Lee, PEOPLE, 31 Dec. 2025
In this study, slow tapering was a gradual reduction in antidepressant dosage over the course of four weeks or more.
—Emily Kay Votruba, EverydayHealth.com, 11 Dec. 2025
Noun
The device, the FL-100 from Flow Neuroscience, will be available via clinician for people aged 18 years and older with MDD, either as a standalone intervention or as an adjunct to existing therapies such as antidepressants.
—New Atlas, 4 Jan. 2026
Mehta also noted that the findings are not a substitute for traditional antidepressants.
—Deirdre Bardolf, FOXNews.com, 3 Jan. 2026
See All Example Sentences for antidepressant
Cite this Entry
“Antidepressant.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/antidepressant. Accessed 8 Jan. 2026.
Copy CitationMedical Definition
antidepressant
1 of 2 adjective
an·ti·de·pres·sant
ˌant-i-di-ˈpres-ᵊnt, ˌan-ˌtī-
variants
also antidepressive
: used or tending to relieve or prevent psychological depression : relating to, being, or utilizing an antidepressant
an antidepressant drug
antidepressant treatment
antidepressant
2 of 2 noun
variants
also antidepressive
: a drug used to treat psychological depression : an antidepressant drug
The dual-action antidepressant venlafaxine appears to demonstrate superior efficacy and higher rates of remission in severe depression as compared with either SSRIs such as fluoxetine or tricyclic antidepressants.—John Mann, The New England Journal of Medicine
John Mann, The New England Journal of Medicinecalled also energizer, psychic energizer, psychostimulant
see tricyclic antidepressantLove words? Need even more definitions?
Merriam-Webster unabridged
Share