Medical Definition of anti–idiotype
: an antibody that binds to the antigen combining site of another antibody either suppressing or enhancing the immune response Anti-idiotypes are secondary antibodies manufactured by the immune system in reaction to the presence of antibodies, the body's basic germ fighters.—Craig D. Rose, The San Diego Union-Tribune, 11 Mar. 1988
anti–idiotypic\-ˌid-ē-ə-ˈtip-ik\ play adjective Recent studies … indicate, however, that other cancer cells expressing a different idiotype can emerge during anti-idiotype treatment.—Ronald C. Kennedy et al., Scientific American, July 1986 Anti-idiotypic antibodies that bind to the idiotype marker (antigen-binding site) on B cells, may also suppress autoantibody production.—Jacqueline Parkin and Bryony Cohen, The Lancet, 2 June 2001
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