haplotype

noun

hap·​lo·​type ˈha-plō-ˌtīp How to pronounce haplotype (audio)
: a group of alleles of different genes (as of the major histocompatibility complex) on a single chromosome that are closely enough linked to be inherited usually as a unit

Examples of haplotype in a Sentence

Recent Examples on the Web Specific combinations of these mutations—called a haplotype—seem to confer a higher risk of developing type 1 diabetes. Amanda Gardner, Health, 20 Nov. 2023 In the absence of allelic competitors this variant sweeps up in frequency extremely rapidly, and flanking regions of the genome generate a long haplotype block. Razib Khan, Discover Magazine, 13 Sep. 2013 On the other hand, the haplotype which is present in both the Basque and Punjabis is likely to be descended from a common set of individuals, implying that there is a genealogical chain connecting these two very distinct and distant Eurasian populations. Razib Khan, Discover Magazine, 16 Jan. 2012 And Genghis Khan left his personal imprint on the populations of today, in the form of a set of genes, called a haplotype, common to about 0.5 percent of men today. Nathaniel Scharping, Discover Magazine, 17 Oct. 2020 In 2018, Guanchen Li and Jeremy Austin, also at the University of Adelaide, obtained the entire mitochondrial genome from hair-root material and narrowed down the maternal haplotype to H4a1a1a. IEEE Spectrum, 20 Mar. 2023 In a previous investigation, Pryde et al. discovered that introducing simple substitutions on a benzothiazinone molecule like compound 4 (not shown) could transform it from being a weak activator of the HAQ STING haplotype to one that was highly potent. William A. Haseltine, Forbes, 26 Apr. 2022 The data used in the paper are drawn from the Y chromosome haplotype reference database (YHRD), based at Charité, which includes Y chromosome data from more than 300,000 individuals uploaded by contributors from around the world and is used by researchers and law enforcement agencies. Dennis Normile, Science | AAAS, 10 Aug. 2021 But the haplotype structure mitigates against this. Razib Khan, Discover Magazine, 27 Aug. 2012 See More

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'haplotype.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

First Known Use

1967, in the meaning defined above

Time Traveler
The first known use of haplotype was in 1967

Dictionary Entries Near haplotype

Cite this Entry

“Haplotype.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/haplotype. Accessed 29 Feb. 2024.

Medical Definition

haplotype

noun
hap·​lo·​type -ˌtīp How to pronounce haplotype (audio)
: a group of alleles of different genes (as of the major histocompatibility complex) on a single chromosome that are closely enough linked to be inherited usually as a unit

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