poly·​clon·​al ˌpä-lē-ˈklō-nəl How to pronounce polyclonal (audio)
: produced by, involving, or being cells derived from two or more cells of different ancestry or genetic constitution
polyclonal antibody synthesis
polyclonal activation of T cells

Examples of polyclonal in a Sentence

Recent Examples on the Web The polyclonal antibody treatment, called SAB-185, is the first of its kind in the ACTIV-2 Outpatient Monoclonal Antibodies and Other Therapies Trial, which is led by the AIDS Clinical Trial Group and sponsored by the National Institute of Allergy and Infectious Diseases. Dallas News, 4 Jan. 2022 Regeneron Pharmaceuticals shares were 3.7% higher in pre-market trading after news broke on Friday that Regeneron's polyclonal antibody cocktail was part of Trump's COVID treatment. Bernhard Warner, Fortune, 5 Oct. 2020 Trump, while still at the White House, received a single 8-gram dose of a polyclonal antibody combination drug while also taking zinc, vitamin D, melatonin, aspirin and famotidine, a heartburn medicine, according to White House physician Dr. Sean Conley. Star Tribune, 2 Oct. 2020 The president received a single 8 gram dose of Regeneron's experimental polyclonal antibody cocktail as a precautionary measure, Conley said. Michael James, USA TODAY, 3 Oct. 2020 Researchers at the University of Texas Southwestern Medical Center are studying a polyclonal antibody therapy to treat nonhospitalized people with early COVID-19 as part of a national effort to keep patients with the virus out of the hospital. Dallas News, 4 Jan. 2022 Variants resistant to the neutralizing activity of such polyclonal sera develop in a matter of days to weeks. William A. Haseltine, Forbes, 4 Jan. 2022 Vaccines generate what’s called a polyclonal response, with lots of antibodies that recognize different pieces of the spike protein. Andrew Joseph, STAT, 30 Nov. 2021 Unlike monoclonal antibody therapies, vaccines (especially those using the whole spike protein) make polyclonal antibody responses. Sarah Jacoby, SELF, 21 Dec. 2020 See More

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'polyclonal.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History


poly- + clonal

First Known Use

1914, in the meaning defined above

Time Traveler
The first known use of polyclonal was in 1914

Dictionary Entries Near polyclonal

Cite this Entry

“Polyclonal.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/polyclonal. Accessed 2 Dec. 2023.

Medical Definition


poly·​clo·​nal ˈpäl-i-ˌklōn-ᵊl How to pronounce polyclonal (audio)
: produced by or being cells derived from two or more cells of different ancestry or genetic constitution
polyclonal antibody synthesis
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