monoclonal

adjective
mono·​clo·​nal | \ ˌmä-nə-ˈklō-nᵊl How to pronounce monoclonal (audio) \

Definition of monoclonal

 (Entry 1 of 2)

: produced by, being, composed of, or caused by cells derived from a single cell … Dr. [Lawrence] Kaplan said tumors that were monoclonal, arising from a single malignant cell, indicated poor survival.— Marilyn Chase especially : relating to, being, or caused by a monoclonal antibody or monoclonal antibodies monoclonal assays — see also monoclonal gammopathy

monoclonal

noun
plural monoclonals

Definition of monoclonal (Entry 2 of 2)

: monoclonal antibody But now researchers say that new ways of modifying antibodies promise to deliver monoclonals in more effective forms, with fewer side effects and at lower cost.— Lawrence M. Fisher

Examples of monoclonal in a Sentence

Recent Examples on the Web: Adjective To make what's called monoclonal antibodies for an antibody cocktail, scientists comb through thousands of antibodies to figure out which ones fight the novel coronavirus most effectively. Jacqueline Howard, CNN, "Regeneron starts Phase 3 trial of Covid antibody drug that might treat and prevent infection, company says," 6 July 2020 The medicine, a monoclonal antibody, will be tested for both treating and preventing infection in patients who have been exposed to the disease. Matthew Herper, STAT, "Eli Lilly’s Dan Skovronsky on Covid-19, Alzheimer’s, and the place of entrepreneurs in pharma," 7 July 2020 To make what's called monoclonal antibodies for an antibody cocktail, scientists comb through thousands of antibodies to figure out which ones fight the novel coronavirus most effectively. Jacqueline Howard, CNN, "Regeneron starts Phase 3 trial of Covid antibody drug that might treat and prevent infection, company says," 6 July 2020 Regeneron’s drug, REGN-COV2, is among the most advanced in a class of medicines known as monoclonal antibodies being developed to treat Covid-19. Joseph Walker, WSJ, "Regeneron Advances Covid-19 Drug Into Later-Stage Testing," 6 July 2020 This approach used monoclonal antibodies that stick to the SARS spike protein and prevent it from binding to ACE2 receptors in our body. William A. Haseltine, Scientific American, "Lessons for COVID-19 from the Early Days of AIDS," 6 July 2020 Already registered in Nigeria, Ghana and Kenya, the test utilizes specific and sensitive monoclonal antibodies that are embedded on a test strip to detect hemoglobins A, S, and C. Paul Adepoju, Quartz Africa, "A 10-minute test could solve Africa’s sickle cell disease screening problem for newborns," 25 June 2020 At least 6 companies are developing monoclonal antibodies that are ready for testing in people. Ken Alltucker, USA TODAY, "NIH director: COVID-19's 'heartbreaking' harm to Black and Hispanic Americans demands testing," 23 June 2020 Another monoclonal antibody, leronlimab, is being studied in coronavirus clinical trials by its Washington state drugmaker, CytoDyn. Peter Fimrite, SFChronicle.com, "Efforts at coronavirus vaccines and treatments abound in the Bay Area," 22 June 2020

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'monoclonal.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of monoclonal

Adjective

1914, in the meaning defined above

Noun

1980, in the meaning defined above

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Time Traveler for monoclonal

Time Traveler

The first known use of monoclonal was in 1914

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Statistics for monoclonal

Last Updated

30 Jul 2020

Cite this Entry

“Monoclonal.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/monoclonal. Accessed 4 Aug. 2020.

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More Definitions for monoclonal

monoclonal

adjective
mono·​clo·​nal | \ ˌmän-ə-ˈklōn-ᵊl How to pronounce monoclonal (audio) \

Medical Definition of monoclonal

 (Entry 1 of 2)

: produced by, being, or composed of cells derived from a single cell a monoclonal tumor especially : relating to or being an antibody derived from a single cell in large quantities for use against a specific antigen (as a cancer cell)

monoclonal

noun

Medical Definition of monoclonal (Entry 2 of 2)

: a monoclonal antibody

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