mono·​clo·​nal | \ ˌmä-nə-ˈklō-nᵊl How to pronounce monoclonal (audio) \

Definition of monoclonal

: produced by, being, or composed of cells derived from a single cell

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Other Words from monoclonal

monoclonal noun

Examples of monoclonal in a Sentence

Recent Examples on the Web

Later, the pharmacopoeia expanded to include large and complex proteins—from insulin to monoclonal antibodies. Siddhartha Mukherjee, The New Yorker, "The Promise and Price of Cellular Therapies," 15 July 2019 Drugs derived from recombinant DNA and those made with another biotech method—monoclonal antibody technology—dominated drug development. Henry I. Miller, WSJ, "Follow the FDA’s Self-Interest," 28 Oct. 2018 The monoclonal antibody daratumumab, sold by the Janssen unit of Johnson & Johnson under the brand name Darzalex, was first approved in 2015 for people with late-stage disease. Karen Weintraub, STAT, "Once quickly lethal and still humbling, multiple myeloma may be in a ‘golden age’ of treatment," 29 May 2018 Still, monoclonal antibody treatment will not be for everyone. R. Allan Purdy, Scientific American, "Can Anything Stop My Migraine?," 1 May 2017 Four experimental treatments for Ebola were sent to the region: ZMapp, which was tried in West Africa; GS-5734, an antiviral drug; and two monoclonal antibodies, REGN-EB3 and Ma b114. New York Times, "Ebola Outbreak in Central Africa Is ‘Largely Contained’," 28 June 2018 But monoclonal antibodies like the new drugs are grown in living cells and expensive to produce. New York Times, "F.D.A. Approves First Drug Designed to Prevent Migraines," 17 May 2018 He and Birndorf thought that the then-exotic field of monoclonal antibodies would provide a better way. Bradley J. Fikes,, "HybriToast for Hybritech, biotech funding, and neuronal cookbook," 10 May 2018 Some decided to target CGRP or its receptor with a monoclonal antibody. R. Allan Purdy, Scientific American, "Can Anything Stop My Migraine?," 1 May 2017

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'monoclonal.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of monoclonal

1914, in the meaning defined above

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Last Updated

25 Jul 2019

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Time Traveler for monoclonal

The first known use of monoclonal was in 1914

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More Definitions for monoclonal


mono·​clo·​nal | \ ˌmän-ə-ˈklōn-ᵊl How to pronounce monoclonal (audio) \

Medical Definition of monoclonal

 (Entry 1 of 2)

: produced by, being, or composed of cells derived from a single cell a monoclonal tumor especially : relating to or being an antibody derived from a single cell in large quantities for use against a specific antigen (as a cancer cell)



Medical Definition of monoclonal (Entry 2 of 2)

: a monoclonal antibody

Comments on monoclonal

What made you want to look up monoclonal? Please tell us where you read or heard it (including the quote, if possible).


a period when something is suspended

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